Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 2401-2406, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Toft, A. D.
Right arrow Articles by Pedersen, B. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Toft, A. D.
Right arrow Articles by Pedersen, B. K.
Vol. 89, Issue 6, 2401-2406, December 2000

N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise

Anders Dyhr Toft1,2, Mette Thorn3, Kenneth Ostrowski1,2, Sven Asp4, Kirsten Møller2, Susanne Iversen2, Claus Hermann2, Sisse Rye Søndergaard2, and Bente Klarlund Pedersen1,2

1 The Copenhagen Muscle Research Centre, 2 The Department of Infectious Diseases, Rigshospitalet, 3 The Technical University of Denmark, and 4 The August Krogh Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark

The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation (n = 10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation (n = 10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-alpha , interleukin-6, and transforming growth factor-beta 1 peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interlukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise.

interleukin; sport; muscle


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. M. W. Petersen and B. K. Pedersen
The anti-inflammatory effect of exercise
J Appl Physiol, April 1, 2005; 98(4): 1154 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Steensberg, C. Keller, R. L. Starkie, T. Osada, M. A. Febbraio, and B. K. Pedersen
IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1272 - E1278.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. D. Toft, L. B. Jensen, H. Bruunsgaard, T. Ibfelt, J. Halkjar-Kristensen, M. Febbraio, and B. K. Pedersen
Cytokine response to eccentric exercise in young and elderly humans
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C289 - C295.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
K. Krzywkowski, E. W. Petersen, K. Ostrowski, J. H. Kristensen, J. Boza, and B. K. Pedersen
Effect of glutamine supplementation on exercise-induced changes in lymphocyte function
Am J Physiol Cell Physiol, October 1, 2001; 281(4): C1259 - C1265.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Krzywkowski, E. W. Petersen, K. Ostrowski, H. Link-Amster, J. Boza, J. Halkjaer-Kristensen, and B. K. Pedersen
Effect of glutamine and protein supplementation on exercise-induced decreases in salivary IgA
J Appl Physiol, August 1, 2001; 91(2): 832 - 838.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online