Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 2344-2351, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De-Doncker, L.
Right arrow Articles by Falempin, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De-Doncker, L.
Right arrow Articles by Falempin, M.
Vol. 89, Issue 6, 2344-2351, December 2000

Effects of cutaneous receptor stimulation on muscular atrophy developed in hindlimb unloading condition

Laurent De-Doncker, Florence Picquet, and Maurice Falempin

Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille 1, F-59655 Villeneuve d'Ascq Cedex, France

The aim of this study was to investigate whether stimulation of the cutaneous mechanoreceptors of the rat foot sole could partially or totally prevent the soleus muscle atrophy developed after 14 days in hindlimb unloading conditions. Final experiments were achieved under deep anesthesia using pentobarbital sodium (60 mg/kg, ip injection). Atrophy was characterized by a significant decrease in muscle wet weight, fiber size, maximal twitch and tetanic tensions, contraction kinetics, and histochemical and electrophoretical changes. Our data demonstrate that the stimulation of these mechanoreceptors partially prevents the decrease in muscle weight (53%) and cross-sectional area of the soleus muscle (36%) and in all fiber types (type I: 31%; type Ic: 40%; type IIc: 49%; and type IIa: 44%) and also prevented the reductions in strength (peak twitch tension: 31%; peak tetanic tension: 25%). However, the decrease in contraction kinetics was not counteracted. Moreover, histochemical and electrophoretical changes were partially slowed. Thus our results suggest that stimulation of the sole mechanoreceptors can be used, in part, as a countermeasure to the muscular atrophy observed after a period of hindlimb unloading.

countermeasure; plantar surface activation; simulated microgravity


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. J. Kim, R. R. Roy, H. Zhong, H. Suzuki, L. Ambartsumyan, F. Haddad, K. M. Baldwin, and V. R. Edgerton
Electromechanical stimulation ameliorates inactivity-induced adaptations in the medial gastrocnemius of adult rats
J Appl Physiol, July 1, 2007; 103(1): 195 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
L. De-Doncker, M. Kasri, F. Picquet, and M. Falempin
Physiologically adaptive changes of the L5 afferent neurogram and of the rat soleus EMG activity during 14 days of hindlimb unloading and recovery
J. Exp. Biol., December 15, 2005; 208(24): 4585 - 4592.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Mounier, V. Montel, F. Picquet, L. Stevens, B. Bastide, and M. Falempin
Dual effect of deafferentation on contractile characteristics and sarcoplasmic reticulum properties in rat soleus fibers
J Appl Physiol, August 1, 2005; 99(2): 542 - 548.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Kyparos, D. L. Feeback, C. S. Layne, D. A. Martinez, and M. S. F. Clarke
Mechanical stimulation of the plantar foot surface attenuates soleus muscle atrophy induced by hindlimb unloading in rats
J Appl Physiol, August 1, 2005; 99(2): 739 - 746.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Totsuka, Y. Nagao, T. Horii, H. Yonekawa, H. Imai, H. Hatta, Y. Izaike, T. Tokunaga, and Y. Atomi
Physical performance and soleus muscle fiber composition in wild-derived and laboratory inbred mouse strains
J Appl Physiol, August 1, 2003; 95(2): 720 - 727.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online