Journal of Applied Physiology Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 2294-2299, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ruble, S. B.
Right arrow Articles by Clifford, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ruble, S. B.
Right arrow Articles by Clifford, P. S.
Vol. 89, Issue 6, 2294-2299, December 2000

Dynamic exercise attenuates sympathetic responsiveness of canine vascular smooth muscle

Stephen B. Ruble, Zoran Valic, John B. Buckwalter, and Philip S. Clifford

Departments of Anesthesiology and Physiology, Medical College of Wisconsin and Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

The phenomenon of reduced responsiveness of the skeletal muscle arterial vasculature to sympathetic activation during exercise (sympatholysis) remains controversial. The purpose of this study was to examine the vascular effects of sympathoactivation in dynamically exercising skeletal muscle. Mongrel dogs (19-24 kg) were instrumented chronically with transit-time ultrasonic flow probes on the external iliac arteries. After pretreatment with atropine (0.2 mg/kg), an intravenous bolus (4 µg/kg) of a nicotinic ganglion stimulant [1,1-dimethyl-4-phenylpiperazinium iodide (DMPP)] was given at rest and during treadmill exercise at graded intensities. Administration of DMPP was associated with prompt reductions in iliac blood flow and increases in arterial pressure under all conditions. There were significant reductions (P < 0.05) in iliac vascular conductance of 58 ± 4 (SE), 48 ± 3, 36 ± 5, and 16 ± 3% at rest, 3 miles/h and 0% grade, 6 miles/h and 0% grade, and 6 miles/h and 15% grade, respectively. These data demonstrate that activation of postganglionic sympathetic nerves with DMPP caused vasoconstriction in the skeletal muscle vasculature at rest and during exercise. Additionally, the magnitude of vasoconstriction was inversely related to exercise intensity. These results support the concept of exercise sympatholysis.

vascular conductance; sympatholysis; blood flow; sympathetic nervous system; adrenergic


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Komine, K. Matsukawa, H. Tsuchimochi, T. Nakamoto, and J. Murata
Sympathetic cholinergic nerve contributes to increased muscle blood flow at the onset of voluntary static exercise in conscious cats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1251 - R1262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. DeLorey, J. J. Hamann, Z. Valic, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter
{alpha}-Adrenergic receptor responsiveness is preserved during prolonged exercise
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H392 - H398.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. J. Hamann, H. A. Kluess, P. S. Clifford, and J. B. Buckwalter
{alpha}-Adrenergic receptor-mediated restraint of skeletal muscle blood flow during prolonged exercise
J Appl Physiol, May 1, 2006; 100(5): 1563 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. D. Thomas and S. S. Segal
Neural control of muscle blood flow during exercise
J Appl Physiol, August 1, 2004; 97(2): 731 - 738.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Buckwalter, J. C. Taylor, J. J. Hamann, and P. S. Clifford
Role of nitric oxide in exercise sympatholysis
J Appl Physiol, July 1, 2004; 97(1): 417 - 423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. B. Buckwalter, J. J. Hamann, H. A. Kluess, and P. S. Clifford
Vasoconstriction in exercising skeletal muscles: a potential role for neuropeptide Y?
Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H144 - H149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. Yamamoto, T. Kawada, A. Kamiya, H. Takaki, T. Miyamoto, M. Sugimachi, and K. Sunagawa
Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc
Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1382 - H1388.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. W. Wray, P. J. Fadel, M. L. Smith, P. Raven, and M. Sander
Inhibition of {alpha}-adrenergic vasoconstriction in exercising human thigh muscles
J. Physiol., March 1, 2004; 555(2): 545 - 563.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. E. Tschakovsky and R. L. Hughson
Rapid blunting of sympathetic vasoconstriction in the human forearm at the onset of exercise
J Appl Physiol, May 1, 2003; 94(5): 1785 - 1792.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online