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J Appl Physiol 89: 2165-2173, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 6, 2165-2173, December 2000

Macromolecule transfer through mesothelium and connective tissue

Francesca Bodega, Luciano Zocchi, and Emilio Agostoni

Istituto di Fisiologia Umana I, Università di Milano, 20133 Milano, Italy

Diffusional permeability (P) to inulin (Pin), albumin (Palb), and dextrans [70 (Pdx 70), 150 (Pdx 150), 550 (Pdx 550), and 2,000 (Pdx 2,000)] was determined in specimens of parietal pericardium of rabbits, which may be obtained with less damage than pleura. Pin, Palb, Pdx 70, Pdx 150, Pdx 550, and Pdx 2,000 were 0.51 ± 0.06 (SE), 0.18 ± 0.03, 0.097 ± 0.021, 0. 047 ± 0.011, 0.025 ± 0.004, and 0.021 ± 0.005 × 10-5 cm/s, respectively. Pin, Palb, and Pdx 70 of connective tissue, obtained after removal of mesothelium from specimens, were 10.3 ± 1.42, 2.97 ± 0.38, and 2.31 ± 0.16 × 10-5 cm/s, respectively. Hence, Pin, Palb, and Pdx 70 of mesothelium were 0.54, 0.20, and 0.10 × 10-5 cm/s, respectively. Inulin (like small solutes) fitted the relationship P-solute radius for restricted diffusion with a 6-nm "pore" radius, whereas macromolecules were much above it. Hence, macromolecule transfer mainly occurs through "large pores" and/or transcytosis. In line with this, the addition of phospholipids on the luminal side (which decreases pore radius to ~1.5 nm) halved Pin but did not change Palb and Pdx 70. Pin is roughly similar in mesothelium and capillary endothelium, whereas P to macromolecules is greater in mesothelium. The albumin diffusion coefficient through connective tissue was 17% of that in water. Mesothelium provides 92% of resistance to albumin diffusion through the pericardium.

albumin; dextrans; diffusional permeability; inulin; phospholipids


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