Journal of Applied Physiology Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 2139-2146, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Suzuki, R.
Right arrow Articles by Freed, A. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Suzuki, R.
Right arrow Articles by Freed, A. N.
Vol. 89, Issue 6, 2139-2146, December 2000

Hypertonic saline aerosol increases airway reactivity in the canine lung periphery

Ryoichi Suzuki and Arthur N. Freed

Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205

Hyperventilation with dry air increases airway surface fluid (ASF) osmolality and causes acute mucosal injury, leukocyte infiltration, and delayed airway obstruction and hyperreactivity in canine peripheral airways. The purpose of this study was to determine whether ASF hypertonicity per se can account for these hyperventilation-associated effects. We first measured ASF osmolality before and after normal (NSC) and hypertonic (HSC) saline aerosol challenges to document the magnitude of hypertonicity produced by these stimuli. We then measured canine peripheral airway resistance and reactivity to hypocapnia and aerosolized histamine before and after NSC and HSC. Cells and eicosanoid mediators recovered in bronchoalveolar lavage fluid at 5 and 24 h after NSC and HSC were examined. We found that HSC but not NSC caused acute ASF hyperosmolality, increased mediator release, and delayed airway hyperreactivity in the absence of mucosal injury and leukocyte infiltration. These observations suggest that ASF hyperosmolality contributes to the development of the late-phase response to hyperventilation and further suggest that hyperventilation-induced mucosal injury independently initiates leukocyte infiltration and late-phase airway obstruction.

airway surface fluid osmolality; airway resistance; prostaglandin; leukotriene


This article has been cited by other articles:


Home page
 Ther Adv Respir DisHome page
M. Baroffio, G. Barisione, E. Crimi, and V. Brusasco
Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview
Therapeutic Advances in Respiratory Disease, August 1, 2009; 3(4): 163 - 174.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. N. Freed, S. McCulloch, T. Meyers, and R. Suzuki
Neurokinins Modulate Hyperventilation-induced Bronchoconstriction in Canine Peripheral Airways
Am. J. Respir. Crit. Care Med., April 15, 2003; 167(8): 1102 - 1108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. S. Davis, B. McKiernan, S. McCullough, S. Nelson Jr., R. E. Mandsager, M. Willard, and K. Dorsey
Racing Alaskan Sled Dogs as a Model of "Ski Asthma"
Am. J. Respir. Crit. Care Med., September 15, 2002; 166(6): 878 - 882.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online