Journal of Applied Physiology
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J Appl Physiol 89: 2130-2138, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 6, 2130-2138, December 2000

Effects of hypoxia and hypercapnia on circadian rhythms in the golden hamster (Mesocricetus auratus)

Tim M. Jarsky1 and Richard Stephenson1,2

Departments of 2 Physiology and 1 Zoology, University of Toronto, Toronto, Ontario, Canada M5S 3G5

This study was designed to determine whether respiratory stimuli can influence the mammalian circadian timing system. Three-hour pulses of hypoxia (inspired O2 concentration = 8%) or hypercapnia (inspired CO2 concentration = 11%) were presented for 7 days at mid-subjective day (circadian time 6-9) under constant darkness. Hypoxic and hypercapnic pulses caused cumulative phase delays of 46.4 ± 6.9 and 25.9 ± 12.3 min, respectively. Distance run per day was significantly reduced on hypoxic and hypercapnic pulse days, compared with nonpulsed days. Phase shifts were correlated with the reduction in daily running activity (multiple r2 = 0.521, P = 0.036), metabolic depression (multiple r2 = 0.772, P < 0.001), and reduction in body temperature (multiple r2 = 0.539, P = 0.027), but not lung ventilation (multiple r2 = 0.306, P = 0.414) during pulses. We conclude that hypoxia and hypercapnia can influence the phase and quantity of activity in free-running hamsters.

body temperature; metabolism; nonphotic stimuli; respiration


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