Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 89: 2107-2116, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 6, 2107-2116, December 2000

Mixed-gas model for predicting decompression sickness in rats

R. S. Lillo1 and E. C. Parker2

1 Biomedical Research Department, Navy Experimental Diving Unit, Panama City, Florida 32407-7015; and 2 Diving and Environmental Physiology Department, Naval Medical Research Institute, Bethesda, Maryland 20889-5607

A mixed-gas model for rats was developed to further explore the role of different gases in decompression and to provide a global model for possible future evaluation of its usefulness for human prediction. A Hill-equation dose-response model was fitted to over 5,000 rat dives by using the technique of maximum likelihood. These dives used various mixtures of He, N2, Ar, and O2 and had times at depth up to 2 h and varied decompression profiles. Results supported past findings, including 1) differences among the gases in decompression risk (He < N2 < Ar) and exchange rate (He > Ar approx  N2), 2) significant decompression risk of O2, and 3) increased risk of decompression sickness with heavier animals. New findings included asymmetrical gas exchange with gas washout often unexpectedly faster than uptake. Model success was demonstrated by the relatively small errors (and their random scatter) between model predictions and actual incidences. This mixed-gas model for prediction of decompression sickness in rats is the first such model for any animal species that covers such a broad range of gas mixtures and dive profiles.

diving; hyperbaric; inert gases; mathematical modeling


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