| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
Isolated,
spontaneously beating rabbit sinoatrial node cells were subjected to
longitudinal stretch, using carbon fibers attached to both ends of the
cell. Their electrical behavior was studied simultaneously in
current-clamp or voltage-clamp mode using the perforated patch
configuration. Moderate stretch (~7%) caused an increase in
spontaneous beating rate (by ~5%) and a reduction in maximum
diastolic and systolic potentials (by ~2.5%), as seen in
multicellular preparations. Mathematical modeling of the stretch intervention showed the experimental results to be compatible with
stretch activation of cation nonselective ion channels, similar to
those found in other cardiac cell populations. Voltage-clamp experiments validated the presence of a stretch-induced current component with a reversal potential near 
11 mV. These data confirm, for the first time, that the positive chronotropic response of the
heart to stretch is, at least in part, encoded on the level of
individual sinoatrial node pacemaker cells; all reported data are in
agreement with a major contribution of stretch-activated cation
nonselective channels to this response.
heart rate; mechanoelectric feedback; stretch-activated channels; modeling; electrophysiology
This article has been cited by other articles:
|
|
 |
|
  Y. Wang, R. W. Joyner, M. B. Wagner, J. Cheng, D. Lai, and B. H. Crawford Stretch-activated channel activation promotes early afterdepolarizations in rat ventricular myocytes under oxidative stress Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1227 - H1235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kockskamper, M. Khafaga, M. Grimm, A. Elgner, S. Walther, A. Kockskamper, D. von Lewinski, H. Post, M. Grossmann, H. Dorge, et al. Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium Cardiovasc Res, September 1, 2008; 79(4): 642 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Mangoni and J. Nargeot Genesis and Regulation of the Heart Automaticity Physiol Rev, July 1, 2008; 88(3): 919 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kohl, C. Bollensdorff, and A. Garny Effects of mechanosensitive ion channels on ventricular electrophysiology: experimental and theoretical models Exp Physiol, March 1, 2006; 91(2): 307 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-R. Kong, N. Bursac, and L. Tung Mechanoelectrical excitation by fluid jets in monolayers of cultured cardiac myocytes J Appl Physiol, June 1, 2005; 98(6): 2328 - 2336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Chowdhary, D Harrington, R S Bonser, J H Coote, and J N Townend Chronotropic effects of nitric oxide in the denervated human heart J. Physiol., June 1, 2002; 541(2): 645 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Herring, J. A. B. Zaman, and D. J. Paterson Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2318 - H2327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kohl, A. D. Nesbitt, P. J. Cooper, and M. Lei Sudden cardiac death by Commotio cordis: role of mechano--electric feedback Cardiovasc Res, May 1, 2001; 50(2): 280 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Verheijck, R. Wilders, and L. N. Bouman Atrio-Sinus Interaction Demonstrated by Blockade of the Rapid Delayed Rectifier Current Circulation, February 19, 2002; 105(7): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
