Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 1979-1984, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kawada, T.
Right arrow Articles by Sunagawa, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kawada, T.
Right arrow Articles by Sunagawa, K.
Vol. 89, Issue 5, 1979-1984, November 2000

Counteraction of aortic baroreflex to carotid sinus baroreflex in a neck suction model

Toru Kawada, Masashi Inagaki, Hiroshi Takaki, Takayuki Sato, Toshiaki Shishido, Teiji Tatewaki, Yusuke Yanagiya, Masaru Sugimachi, and Kenji Sunagawa

Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan

Although neck suction has been widely used in the evaluation of carotid sinus baroreflex function in humans, counteraction of the aortic baroreflex tends to complicate any interpretation of observed arterial pressure (AP) response. To determine whether a simple linear model can account for the AP response during neck suction, we developed an animal model of the neck suction procedure in which changes in carotid distension pressure during neck suction were directly imposed on the isolated carotid sinus. In six anesthetized rabbits, a 50-mmHg pressure perturbation on the carotid sinus decreased AP by -27.4 ± 4.8 mmHg when the aortic baroreflex was disabled. Enabling the aortic baroreflex significantly attenuated the AP response (-21.5 ± 3.8 mmHg, P < 0.01). The observed closed-loop gain during simulated neck suction was well predicted by the open-loop gains of the carotid sinus and aortic baroreflexes using the linear model (-0.43 ± 0.13 predicted vs. -0.41 ± 0.10 measured). We conclude that the linear model can be used as the first approximation to interpret AP response during neck suction.

systems analysis; closed-loop gain; open-loop gain; rabbits


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Ichinose and T. Nishiyasu
Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans
Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1532 - H1538.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Ichinose, M. Saito, A. Kitano, K. Hayashi, N. Kondo, and T. Nishiyasu
Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans
J. Physiol., May 15, 2004; 557(1): 321 - 330.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Keyl, A. Schneider, J. Hobbhahn, and L. Bernardi
Sinusoidal Neck Suction for Evaluation of Baroreflex Sensitivity During Desflurane and Sevoflurane Anesthesia
Anesth. Analg., December 1, 2002; 95(6): 1629 - 1636.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online