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1 Sports Medicine Research Unit and 2 Department of Clinical Physiology, Copenhagen Muscle Research Centre, Bispebjerg Hospital, Copenhagen, Denmark
Using near-infrared
spectroscopy (NIRS) and the tracer indocyanine green (ICG), we
quantified blood flow in calf muscle and around the Achilles tendon
during plantar flexion (1-9 W). For comparison, blood flow in calf
muscle was determined by dye dilution in combination with magnetic
resonance imaging measures of muscle volume, and, for the peritendon
region, blood flow was measured by 133Xe washout. From rest
to a peak load of 9 W, NIRS-ICG blood flow in calf muscle increased
from 2.4 ± 0.2 to 74 ± 5 ml · 100 ml tissue
1 · min1, similar to that
measured by reverse dye (77 ± 6 ml · 100 ml tissue1 · min1). Achilles
peritendon blood flow measured by NIRS-ICG rose with exercise from
2.2 ± 0.5 to 15.1 ± 0.2 ml · 100 ml1 · min1, which was similar to
that determined by 133Xe washout (2.0 ± 0.6 to
14.6 ± 0.3 ml · 100 ml
tissue1 · min1). This is the first
study using NIRS and ICG to quantify regional tissue blood flow during
exercise in humans. Due to its high spatial and temporal resolution,
the technique may be useful for determining regional blood flow
distribution and regulation during exercise in humans.
microvascular perfusion; spectrophotometry muscle; tendon
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