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J Appl Physiol 89: 1859-1867, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 5, 1859-1867, November 2000

A human acinar structure for simulation of realistic alveolar plateau slopes

Brigitte Dutrieue1, Frederique Vanholsbeeck1, Sylvia Verbanck2, and Manuel Paiva1

1 Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070 Brussels, Belgium; and 2 Department of Pneumology, Akademisch Ziekenhuis, Vrije Universiteit Brussel, 1090 Brussels, Belgium

We simulated the intra-acinar contribution to phase III slope (Sacin) for gases of differing diffusivities (He and SF6) by solving equations of diffusive and convective gas transport in multi-branch-point models (MBPM) of the human acinus. We first conducted a sensitivity study of Sacin to asymmetry and its variability in successive generations. Sacin increases were greatest when asymmetry and variability of asymmetry were increased at the level of the respiratory bronchioles (generations 17-18) for He and at the level of the alveolar ducts (generations 20-21) for SF6, corresponding to the location of their respective diffusion fronts. On the basis of this sensitivity study and in keeping with reported acinar morphometry, we built a MBPM that actually reproduced experimental Sacin values obtained in normal subjects for He, N2, and SF6. Ten variants of such a MBPM were constructed to estimate intrinsic Sacin variability owing to peripheral lung structure. The realistic simulation of Sacin in the normal lung and the understanding of how asymmetry affects Sacin for different diffusivity gases make Sacin a powerful tool to detect structural alterations at different depths in the lung periphery.

multi-branch-point models; multiple-breath washout; gas mixing; diffusion-convection interdependence; airway asymmetry; helium; SF6


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