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1 Pulmonary and Critical Care Medicine, Evanston Northwestern Healthcare, Evanston 60201; 2 Northwestern University Medical School, Chicago 60611; and 3 Department of Surgery, University of Chicago, Chicago, Illinois 60616
Adult rats exposed to hyperoxia develop
anorexia, weight loss, and a lung injury characterized by pulmonary
edema and decreased lung liquid clearance. We hypothesized that
maintenance of nutrition during hyperoxia could attenuate
hyperoxia-induced pulmonary edema. To test this hypothesis, we
enterally fed adult male Sprague-Dawley rats via gastrostomy tubes and
exposed them to oxygen (inspired O2 fraction >0.95) for
64 h. In contrast to controls, enterally fed hyperoxic animals did
not lose weight and had smaller pleural effusions and wet-to-dry weight
ratios (a measure of lung edema) that were not different from room air
controls. Enterally fed rats exposed to hyperoxia had increased levels
of mRNA for the Na+-K+-ATPase 
1-
and 
1-subunits and glutathione peroxidase. These findings suggest that maintenance of nutrition during an oxidative lung
injury reduces lung edema, perhaps by allowing for continued expression
and function of protective proteins such as the
Na+-K+-ATPase.
sodium-potassium-adenosine 5'-triphosphatase; glutathione peroxidase; hyperoxia
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