Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 1591-1600, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Topulos, G. P.
Right arrow Articles by Butler, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Topulos, G. P.
Right arrow Articles by Butler, J. P.
Vol. 89, Issue 4, 1591-1600, October 2000

Influence of lung volume on pulmonary microvascular pressure-volume characteristics

George P. Topulos1,2, Richard E. Brown1, and James P. Butler2

1 Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, and 2 Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115

The pressure-volume (P-V) characteristics of the lung microcirculation are important determinants of the pattern of pulmonary perfusion and of red and white cell transit times. Using diffuse light scattering, we measured capillary P-V loops in seven excised perfused dog lobes at four lung volumes, from functional residual capacity (FRC) to total lung capacity (TLC), over a wide range of vascular transmural pressures (Ptm). At Ptm 5 cmH2O, specific compliance of the microvasculature was 8.6%/cmH2O near FRC, decreasing to 2.7%/cmH2O as lung volume increased to TLC. At low lung volumes, the vasculature showed signs of strain stiffening (specific compliance fell as Ptm rose), but stiffening decreased as lung volume increased and was essentially absent at TLC. The P-V loops were smooth without sharp transitions, consistent with vascular distension as the primary mode of changes in vascular volume with changes in Ptm. Hysteresis was small (0.013) at all lung volumes, suggesting that, although surface tension may set basal capillary shape, it does not strongly affect capillary compliance.

capillary; diffuse light scattering; transit time; dog; hysteresis; mechanics


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. P. Butler, R. E. Brown, D. Stamenovic, J. P. Morris, and G. P. Topulos
Effect of surface tension on alveolar surface area
J Appl Physiol, September 1, 2002; 93(3): 1015 - 1022.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. P. Topulos, R. E. Brown, and J. P. Butler
Increased surface tension decreases pulmonary capillary volume and compliance
J Appl Physiol, September 1, 2002; 93(3): 1023 - 1029.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online