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J Appl Physiol 89: 1537-1542, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 4, 1537-1542, October 2000

Alveolar epithelial integrity in athletes with exercise-induced hypoxemia

Michael R. Edwards1, Garth S. Hunte1, Allan S. Belzberg2, A. William Sheel1, Dan F. Worsley2, and Donald C. McKenzie1

1 Allan McGavin Sports Medicine Centre and School of Human Kinetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3; and 2 Division of Nuclear Medicine, Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1

The effect of incremental exercise to exhaustion on the change in pulmonary clearance rate (k) of aerosolized 99mTc-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) and the relationship between k and arterial PO2 (PaO2) during heavy work were investigated. Ten male cyclists (age = 25 ± 2 yr, height = 180.9 ± 4.0 cm, mass = 80.1 ± 9.5 kg, maximal O2 uptake = 5.25 ± 0.35 l/min, mean ± SD) completed a pulmonary clearance test shortly (39 ± 8 min) after a maximal O2 uptake test. Resting pulmonary clearance was completed >= 24 h before or after the exercise test. Arterial blood was sampled at rest and at 1-min intervals during exercise. Minimum PaO2 values and maximum alveolar-arterial PO2 difference ranged from 73 to 92 Torr and from 30 to 55 Torr, respectively. No significant difference between resting k and postexercise k for the total lung (0.55 ± 0.20 vs. 0.57 ± 0.17 %/min, P > 0.05) was observed. Pearson product-moment correlation indicated no significant linear relationship between change in k for the total lung and minimum PaO2 (r = -0.26, P > 0.05). These results indicate that, averaged over subjects, pulmonary clearance of 99mTc-DTPA after incremental maximal exercise to exhaustion in highly trained male cyclists is unchanged, although the sampling time may have eliminated a transient effect. Lack of a linear relationship between k and minimum PaO2 during exercise suggests that exercise-induced hypoxemia occurs despite maintenance of alveolar epithelial integrity.

pulmonary clearance of technetium-99m-diethylenetriaminepentaacetic acid; alveolar epithelium; gas exchange


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