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, IL-6, and TNF-
in blood mononuclear cells
1 Graduate Department of Community Health, Faculty of Medicine, 2 Graduate Department of Exercise Sciences, Faculty of Physical Education and Health, University of Toronto, Toronto M5S 2W6; and 3 Biomedical Sciences Section, Defence and Civil Institute of Environmental Medicine, Toronto, Ontario, Canada M3M 3B9
Physical activity
induces a subclinical inflammatory response, mediated in part by
leukocytes, and manifested by elevated concentrations of circulating
proinflammatory cytokines, including interleukin (IL)-1
, IL-6, and
tumor necrosis factor-
(TNF-). However, the source of the
cytokines that appear during exercise remains unknown. In this study,
we examined exercise-induced changes in plasma cytokine concentrations
and their corresponding mRNA expression in peripheral blood mononuclear
cells. Ten healthy [peak oxygen uptake = 48.8 ± 6.5 (SD)
ml · kg
1 · min1] but
untrained men [age = 25 ± 5 (SD) yr] undertook 3 h of
exercise (cycling and inclined walking) at 60-65% peak oxygen
uptake. Circulating leukocyte subset counts were elevated during and
2 h postexercise but returned to normal within 24 h. Plasma
concentrations of IL-1, IL-6, and TNF- peaked at the end of
exercise and remained elevated at 2 h (IL-6) and up to 24 h
(IL-1 and TNF-) postexercise. Cytokine gene expression in
circulating mononuclear cells was measured by using the reverse
transcriptase-polymerase chain reaction; mRNA accumulation did not
change with exercise. In conclusion, mRNA accumulation of IL-1,
IL-6, and TNF- in circulating mononuclear cells is not affected by
3 h of moderate endurance exercise and does not seem to account
for the observed increases in plasma cytokines.
physical exertion; immune; messenger RNA; peripheral blood
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