Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 1491-1498, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fuller, P. M.
Right arrow Articles by Fuller, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fuller, P. M.
Right arrow Articles by Fuller, C. A.
Vol. 89, Issue 4, 1491-1498, October 2000

Effects of 2-G exposure on temperature regulation, circadian rhythms, and adiposity in UCP2/3 transgenic mice

Patrick M. Fuller1, Craig H. Warden1,2,3, Sean J. Barry3, and Charles A. Fuller1

1 Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, 2 Department of Pediatrics, and 3 Rowe Program in Genetics, School of Medicine, University of California, Davis, California 95616-8519

Altered ambient force environments affect energy expenditure via changes in thermoregulation, metabolism, and body composition. Uncoupling proteins (UCPs) have been implicated as potential enhancers of energy expenditure and may participate in some of the adaptations to a hyperdynamic environment. To test this hypothesis, this study examined the homeostatic and circadian profiles of body temperature (Tb) and activity and adiposity in wild-type and UCP2/3 transgenic mice exposed to 1 and 2 G. There were no significant differences between the groups in the means, amplitudes, or phases of Tb and activity rhythms at either the 1- or 2-G level. Percent body fat was significantly lower in transgenic (5.2 ± 0.2%) relative to the wild-type mice (6.2 ± 0.1%) after 2-G exposure; mass-adjusted mesenteric and epididymal fat pads in transgenic mice were also significantly lower (P < 0.05). The data suggest that 1) the actions of two UCPs (UCP2 and UCP3) do not contribute to an altered energy balance at 2 G, although 2) UCP2 and UCP3 do contribute to the utilization of lipids as a fuel substrate at 2 G.

uncoupling proteins; thermogenesis; lipids; hyperdynamic; energy expenditure


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. M. Fuller, K. M. Baldwin, and C. A. Fuller
Parallel and divergent adaptations of rat soleus and plantaris to chronic exercise and hypergravity
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R442 - R448.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Pecaut, G. M. Miller, G. A. Nelson, and D. S. Gridley
Hypergravity-induced immunomodulation in a rodent model: hematological and lymphocyte function analyses
J Appl Physiol, July 1, 2004; 97(1): 29 - 38.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. M. Murakami, L. Erkman, O. Hermanson, M. G. Rosenfeld, and C. A. Fuller
Evidence for vestibular regulation of autonomic functions in a mouse genetic model
PNAS, December 24, 2002; 99(26): 17078 - 17082.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. M. Fuller, T. A. Jones, S. M. Jones, and C. A. Fuller
Neurovestibular modulation of circadian and homeostatic regulation: Vestibulohypothalamic connection?
PNAS, November 26, 2002; 99(24): 15723 - 15728.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online