Journal of Applied Physiology
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J Appl Physiol 89: 1477-1482, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 4, 1477-1482, October 2000

Hyperbaric oxygen improves contractile function of regenerating rat skeletal muscle after myotoxic injury

Paul Gregorevic, Gordon S. Lynch, and David A. Williams

Department of Physiology, The University of Melbourne, Victoria 3010, Australia

There is growing interest in hyperbaric oxygen (HBO) as an adjunctive treatment for muscle injuries. This experiment tested the hypothesis that periodic inhalation of HBO hastens the functional recovery and myofiber regeneration of skeletal muscle after myotoxic injury. Injection of the rat extensor digitorum longus (EDL) muscle with bupivacaine hydrochloride causes muscle degeneration. After injection, rats breathed air with or without periodic HBO [100% O2 at either 2 or 3 atmospheres absolute (ATA)]. In vitro maximum isometric tetanic force of injured EDL muscles and regenerating myofiber size were unchanged between 2 ATA HBO-treated and untreated rats at 14 days postinjury but were ~11 and ~19% greater, respectively, in HBO-treated rats at 25 days postinjury. Maximum isometric tetanic force of injured muscles was ~27% greater, and regenerating myofibers were ~41% larger, in 3 ATA HBO-treated rats compared with untreated rats at 14 days postinjury. These findings demonstrate that periodic HBO inhalation increases maximum force-producing capacity and enhances myofiber growth in regenerating skeletal muscle after myotoxic injury with greater effect at 3 than at 2 ATA.

bupivacaine hydrochloride; myofiber regeneration


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