Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 89: 1365-1379, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (95)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chakravarthy, M. V.
Right arrow Articles by Booth, F. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chakravarthy, M. V.
Right arrow Articles by Booth, F. W.
Vol. 89, Issue 4, 1365-1379, October 2000

IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle

Manu V. Chakravarthy1, Bradley S. Davis1, and Frank W. Booth1,2

1 Department of Integrative Biology, University of Texas Medical School, Houston, Texas 77030; and 2 Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211

One of the key factors responsible for the age-associated reduction in muscle mass may be that satellite cell proliferation potential (number of doublings contained within each cell) could become rate limiting to old muscle regrowth. No studies have tested whether repeated cycles of atrophy-regrowth in aged animals deplete the remaining capacity of satellite cells to replicate or what measures can be taken to prevent this from happening. We hypothesized that there would be a pronounced loss of satellite cell proliferative potential in gastrocnemius muscles of aged rats (25- to 30-mo-old FBN rats) subjected to three cycles of atrophy by hindlimb immobilization (plaster casts) with intervening recovery periods. Our results indicated that there was a significant loss in gastrocnemius muscle mass and in the proliferative potential of the resident satellite cells after just one bout of immobilization. Neither the muscle mass nor the satellite cell proliferation potential recovered from their atrophied values after either the first 3-wk or later 9-wk recovery period. Remarkably, application of insulin-like growth factor I onto the atrophied gastrocnemius muscle for an additional 2 wk after this 9-wk recovery period rescued ~46% of the lost muscle mass and dramatically increased proliferation potential of the satellite cells from this muscle.

rehabilitation; growth factors; aging; senescence; stem cells; insulin-like growth factor I


This article has been cited by other articles:


Home page
 J. Physiol.Home page
E. E. Spangenburg, D. Le Roith, C. W. Ward, and S. C. Bodine
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
J. Physiol., January 1, 2008; 586(1): 283 - 291.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. M. Bamman, J. K. Petrella, J.-s. Kim, D. L. Mayhew, and J. M. Cross
Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans
J Appl Physiol, June 1, 2007; 102(6): 2232 - 2239.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Wei, J. R. Sowers, R. Nistala, H. Gong, G. M.-E. Uptergrove, S. E. Clark, E. M. Morris, N. Szary, C. Manrique, and C. S. Stump
Angiotensin II-induced NADPH Oxidase Activation Impairs Insulin Signaling in Skeletal Muscle Cells
J. Biol. Chem., November 17, 2006; 281(46): 35137 - 35146.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. K. Petrella, J.-s. Kim, J. M. Cross, D. J. Kosek, and M. M. Bamman
Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E937 - E946.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Shi and D. J. Garry
Muscle stem cells in development, regeneration, and disease.
Genes & Dev., July 1, 2006; 20(13): 1692 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
J Appl Physiol, April 1, 2006; 100(4): 1188 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Lees, C. R. Rathbone, and F. W. Booth
Age-associated decrease in muscle precursor cell differentiation
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C609 - C615.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
R. T. Hepple
Dividing to Keep Muscle Together: The Role of Satellite Cells in Aging Skeletal Muscle
Sci. Aging Knowl. Environ., January 18, 2006; 2006(3): pe3 - pe3.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
M. Sitnick, A. M. Foley, M. Brown, and E. E. Spangenburg
Ovariectomy prevents the recovery of atrophied gastrocnemius skeletal muscle mass
J Appl Physiol, January 1, 2006; 100(1): 286 - 293.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. S. Brack, H. Bildsoe, and S. M. Hughes
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
J. Cell Sci., October 15, 2005; 118(20): 4813 - 4821.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Westerkamp and S. E. Gordon
Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1223 - R1231.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. A. Sanchez, L. M. Snow, D. A. Lowe, R. C. Serfass, and L. V. Thompson
Effects of endurance exercise-training on single-fiber contractile properties of insulin-treated streptozotocin-induced diabetic rats
J Appl Physiol, August 1, 2005; 99(2): 472 - 478.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Leeuwenburgh, C. M. Gurley, B. A. Strotman, and E. E. Dupont-Versteegden
Age-related differences in apoptosis with disuse atrophy in soleus muscle
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1288 - R1296.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, F. Zaldivar, D. M. Cooper, and G. R. Adams
IL-6-induced skeletal muscle atrophy
J Appl Physiol, March 1, 2005; 98(3): 911 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J.-s. Kim, K. W. Hinchcliff, M. Yamaguchi, L. A. Beard, C. D. Markert, and S. T. Devor
Exercise training increases oxidative capacity and attenuates exercise-induced ultrastructural damage in skeletal muscle of aged horses
J Appl Physiol, January 1, 2005; 98(1): 334 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Dasarathy, M. Dodig, S. M. Muc, S. C. Kalhan, and A. J. McCullough
Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat
Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1124 - G1130.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. O. Mitchell and G. K. Pavlath
Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1753 - C1762.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Iida, E. Itoh, D.-S. Kim, J. P del Rincon, K. T Coschigano, J. J Kopchick, and M. O Thorner
Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice
J. Physiol., October 15, 2004; 560(2): 341 - 349.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Kamei, S. Miura, M. Suzuki, Y. Kai, J. Mizukami, T. Taniguchi, K. Mochida, T. Hata, J. Matsuda, H. Aburatani, et al.
Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control
J. Biol. Chem., September 24, 2004; 279(39): 41114 - 41123.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Carotta, S. Pilat, A. Mairhofer, U. Schmidt, H. Dolznig, P. Steinlein, and H. Beug
Directed differentiation and mass cultivation of pure erythroid progenitors from mouse embryonic stem cells
Blood, September 15, 2004; 104(6): 1873 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Gallegly, N. A. Turesky, B. A. Strotman, C. M. Gurley, C. A. Peterson, and E. E. Dupont-Versteegden
Satellite cell regulation of muscle mass is altered at old age
J Appl Physiol, September 1, 2004; 97(3): 1082 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
V. Sartorelli and M. Fulco
Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy
Sci. Signal., August 3, 2004; 2004(244): re11 - re11.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Hameed, K. H. W. Lange, J. L. Andersen, P. Schjerling, M. Kjaer, S. D. R. Harridge, and G. Goldspink
The effect of recombinant human growth hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men
J. Physiol., February 15, 2004; 555(1): 231 - 240.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. T. Morris, E. E. Spangenburg, and F. W. Booth
Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
J Appl Physiol, January 1, 2004; 96(1): 398 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. B. P. CHARGE and M. A. RUDNICKI
Cellular and Molecular Regulation of Muscle Regeneration
Physiol Rev, January 1, 2004; 84(1): 209 - 238.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
R. T. Hepple
Sarcopenia--A Critical Perspective
Sci. Aging Knowl. Environ., November 19, 2003; 2003(46): pe31 - 31.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
A. E. Barani, A.-C. Durieux, O. Sabido, and D. Freyssenet
Age-related changes in the mitotic and metabolic characteristics of muscle-derived cells
J Appl Physiol, November 1, 2003; 95(5): 2089 - 2098.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Pattison, L. C. Folk, R. W. Madsen, and F. W. Booth
Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy
J Appl Physiol, November 1, 2003; 95(5): 2171 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
E. Barton and C. Morris
Review Article: Mechanisms and Strategies to Counter Muscle Atrophy
J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2003; 58(10): M923 - 926.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. S. Pattison, L. C. Folk, R. W. Madsen, T. E. Childs, and F. W. Booth
Transcriptional profiling identifies extensive downregulation of extracellular matrix gene expression in sarcopenic rat soleus muscle
Physiol Genomics, September 29, 2003; 15(1): 34 - 43.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
E. I. Dedkov, A. B. Borisov, A. Wernig, and B. M. Carlson
Aging of Skeletal Muscle Does Not Affect the Response of Satellite Cells to Denervation
J. Histochem. Cytochem., July 1, 2003; 51(7): 853 - 863.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Bouscary, F. Pene, Y.-E. Claessens, O. Muller, S. Chretien, M. Fontenay-Roupie, S. Gisselbrecht, P. Mayeux, and C. Lacombe
Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation
Blood, May 1, 2003; 101(9): 3436 - 3443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. J. Hawke, N. Jiang, and D. J. Garry
Absence of p21CIP Rescues Myogenic Progenitor Cell Proliferative and Regenerative Capacity in Foxk1 Null Mice
J. Biol. Chem., January 31, 2003; 278(6): 4015 - 4020.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. Gregorevic, D. R. Plant, K. S. Leeding, L. A. Bach, and G. S. Lynch
Improved Contractile Function of the mdx Dystrophic Mouse Diaphragm Muscle after Insulin-Like Growth Factor-I Administration
Am. J. Pathol., December 1, 2002; 161(6): 2263 - 2272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. B. P. Charge, A. S. Brack, and S. M. Hughes
Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy
Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1228 - C1241.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Adams
Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation
J Appl Physiol, September 1, 2002; 93(3): 1159 - 1167.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. W. Booth, M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
J Appl Physiol, July 1, 2002; 93(1): 3 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. E. Spangenburg and F. W. Booth
Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C204 - C211.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. R. Barton, L. Morris, A. Musaro, N. Rosenthal, and H. L. Sweeney
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice
J. Cell Biol., April 1, 2002; 157(1): 137 - 148.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Hawke and D. J. Garry
Myogenic satellite cells: physiology to molecular biology
J Appl Physiol, August 1, 2001; 91(2): 534 - 551.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. E. Mozdziak, P. M. Pulvermacher, and E. Schultz
Muscle regeneration during hindlimb unloading results in a reduction in muscle size after reloading
J Appl Physiol, July 1, 2001; 91(1): 183 - 190.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
S.M. Roth, G.F. Martel, F.M. Ivey, J.T. Lemmer, B.L. Tracy, E.J. Metter, B.F. Hurley, and M.A. Rogers
Skeletal Muscle Satellite Cell Characteristics in Young and Older Men and Women After Heavy Resistance Strength Training
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2001; 56(6): B240 - B247.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Chakravarthy, T. W. Abraha, R. J. Schwartz, M. L. Fiorotto, and F. W. Booth
Insulin-like Growth Factor-I Extends in Vitro Replicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3'-Kinase/Akt Signaling Pathway
J. Biol. Chem., November 10, 2000; 275(46): 35942 - 35952.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. R. Barton, L. Morris, A. Musaro, N. Rosenthal, and H. L. Sweeney
Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice
J. Cell Biol., April 1, 2002; 157(1): 137 - 148.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online