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J Appl Physiol 89: 1340-1344, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 4, 1340-1344, October 2000

Effects of beta -hydroxy-beta -methylbutyrate on muscle damage after a prolonged run

A. E. Knitter, L. Panton, J. A. Rathmacher, A. Petersen, and R. Sharp

Human Performance Laboratory, Iowa State University, Ames, Iowa 50011

This study examined the effects of supplemental beta -hydroxy-beta -methylbutyrate (HMB) on muscle damage as a result of intense endurance exercise. Subjects (n = 13) were paired according to their 2-mile run times and past running experience. Each pair was randomly assigned a treatment of either HMB (3 g/day) or a placebo. After 6 wk of daily training and supplementation, all subjects participated in a prolonged run (20-km course). Creatine phosphokinase and lactate dehydrogenase (LDH) activities were measured before and after a prolonged run to assess muscle damage. The placebo-supplemented group exhibited a significantly greater (treatment main effect, P = 0.05) increase in creatine phosphokinase activity after a prolonged run than did the HMB-supplemented group. In addition, LDH activity was significantly lower (treatment main effect, P = 0.003) with HMB supplementation compared with the placebo-supplemented group. In conclusion, supplementation with 3.0 g of HMB results in a decreased creatine phosphokinase and LDH response after a prolonged run. These findings support the hypothesis that HMB supplementation helps prevent exercise-induced muscle damage.

endurance exercise; recovery; running


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