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O2 on-kinetics in canine muscle
contracting at peak O2
1 Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale delle Ricerche, I-20090 Segrate (MI), Italy; 2 Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0623; and 3 Department of Health and Human Performance, Auburn University, Auburn, Alabama 36849-5323
A
previous study (Grassi B, Gladden LB, Samaja M, Stary CM, and Hogan MC,
J Appl Physiol 85: 1394-1403, 1998) showed that convective O2 delivery to muscle did not limit
O2 uptake (
O2) on-kinetics
during transitions from rest to contractions at ~60% of peak
O2. The present study aimed to
determine whether this finding is also true for transitions involving
contractions of higher metabolic intensities.
O2 on-kinetics were determined in
isolated canine gastrocnemius muscles in situ (n = 5)
during transitions from rest to 4 min of electrically stimulated
isometric tetanic contractions corresponding to the muscle peak
O2. Two conditions were compared:
1) spontaneous adjustment of muscle blood flow (
)
(Control) and 2) pump-perfused , adjusted
~15-30 s before contractions at a constant level corresponding
to the steady-state value during contractions in Control (Fast
O2 Delivery). In Fast O2 Delivery, adenosine
was infused intra-arterially. was measured continuously in the
popliteal vein; arterial and popliteal venous O2 contents
were measured at rest and at 5- to 7-s intervals during the transition.
Muscle O2 was determined as
times the arteriovenous blood O2 content difference. The time to reach 63% of the O2 difference
between resting baseline and steady-state values during contractions
was 24.9 ± 1.6 (SE) s in Control and 18.5 ± 1.8 s in
Fast O2 Delivery (P < 0.05). Faster
O2 on-kinetics in Fast O2
Delivery was associated with an ~30% reduction in the calculated
O2 deficit and with less muscle fatigue. During transitions
involving contractions at peak O2, convective O2 delivery to muscle, together with an inertia
of oxidative metabolism, contributes in determining the
O2 on-kinetics.
gas-exchange kinetics; skeletal muscle oxidative metabolism; maximal contractions
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