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J Appl Physiol 89: 869-876, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 3, 869-876, September 2000

CUTTING-EDGE REPORT
Series-to-parallel transition in the filament lattice of airway smooth muscle

Chun Y. Seow, Victor R. Pratusevich, and Lincoln E. Ford

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Force-velocity curves measured at different times during tetani of sheep trachealis muscle were analyzed to assess whether velocity slowing could be explained by thick-filament lengthening. Such lengthening increases force by placing more cross bridges in parallel on longer filaments and decreases velocity by reducing the number of filaments spanning muscle length. From 2 s after the onset of stimulation, when force had achieved 42% of it final value, to 28 s, when force had been at its tetanic plateau for ~15 s, velocity decreases were exactly matched by force increases when force was adjusted for changes in activation, as assessed from the maximum power value in the force-velocity curves. A twofold change in velocity could be quantitatively explained by a series-to-parallel change in the filament lattice without any need to postulate a change in cross-bridge cycling rate.

sheep; smooth muscle activation; smooth muscle contraction; muscle velocity; myosin


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