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J Appl Physiol 89: 1233-1238, 2000; Free Article
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Vol. 89, Issue 3, 1233-1238, September 2000

HIGHLIGHTED TOPICS
Physiology of a Microgravity Environment
Selected Contribution: Measuring the response time of pulmonary capillary recruitment to sudden flow changes

Eric M. Jaryszak1, William A. Baumgartner Jr2, Amanda J. Peterson2, Robert G. Presson Jr2, Robb W. Glenny4, and Wiltz W. Wagner Jr1,2,3

Departments of 1 Physiology/Biophysics, 2 Anesthesia, and 3 Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202; and 4 Departments of Medicine and of Physiology and Biophysics, University of Washington School of Medicine, Seattle, Washington 98195

To determine how rapidly pulmonary capillaries recruit after sudden changes in blood flow, we used an isolated canine lung lobe perfused by two pumps running in parallel. When one pump was turned off, flow was rapidly halved; when it was turned on again, flow immediately doubled. We recorded pulmonary capillary recruitment in subpleural alveoli using videomicroscopy to measure how rapidly the capillaries reached a new steady state after these step changes in blood flow. When flow was doubled, capillary recruitment reached steady state in <4 s. When flow was halved, steady state was reached in ~8 s. We conclude that the pulmonary microcirculation responds rapidly to step changes in flow, even in the capillaries that are most distant from the hilum.

microcirculation; videomicroscopy; dogs


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