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J Appl Physiol 89: 1005-1012, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 3, 1005-1012, September 2000

Dual effects of nitric oxide on cat carotid body chemoreception

Rodrigo Iturriaga, Sandra Villanueva, and Matias Mosqueira

Laboratorio de Neurobiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 1, Chile

We studied the effects of nitric oxide (NO) released by NO donors on cat carotid body (CB) chemosensory activity during normoxia and hypoxia. CBs excised from pentobarbital sodium-anaesthetized cats were perfused with Tyrode at 38°C and pH 7.40. The frequency of chemosensory discharges (f x) was recorded from the carotid sinus nerve, and changes of NO concentration were measured by a chronoamperometric technique, with NO-selective carbon-fiber microelectrodes inserted in the CB. During steady chemosensory excitation induced by hypoxia, bolus injections of NO (Delta NO = 0.5-12 µM), released by S-nitroso-N-acetylpenicillamine (SNAP) and 6-(2-hydroxy-1-methyl-nitrosohydrazino)-N-methyl-1-hexanamine (NOC-9), transiently reduced f x in a dose-dependent manner. However, during normoxia, the same concentration of NO (Delta NO = 0.5-13 µM) released by the NO donors increased f x in a dose-dependent manner. The present results show a dual effect of NO on CB chemoreception that is dependent on the PO2 levels. During hypoxia, NO is predominantly an inhibitor of chemoreception, whereas, in normoxia, NO increased f x. The mechanisms by which NO produces chemosensory excitation during normoxia remain to be determined.

dual effect; hypoxia; oxygen


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