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1 Second Department of Physiology, Showa University School of Medicine, Tokyo 142-8555; and 2 Department of Chest Medicine, Chiba University School of Medicine, Chiba 260-8670, Japan
Breathing pattern is influenced by body temperature. However,
the central mechanism for changing breathing patterns is unknown. Central histamine is involved in heat loss mechanisms in behavioral studies, but little is known about its effect on breathing patterns. We
examined first the effect of body temperature on breathing patterns
with increasing hypercapnia in conscious mice and then that of the
depletion of central histamine by S(+)-
-fluoromethylhistidine hydrochloride (-FMH) (100 mg/kg ip), a specific inhibitor of histidine decarboxylase, at normal and raised body temperatures. A
raised body temperature increased respiratory frequency with reductions
in both inspiratory and expiratory time and decreased tidal volume. On
the other hand, -FMH lowered respiratory frequency with a
prolongation of expiratory time at the raised temperature; however,
this was not observed at a normal temperature. These results indicate
that central histamine contributes to an increase in respiratory
frequency as a result of a reduction in expiratory time when body
temperature is raised.
breathing pattern; carbon dioxide; -fluoromethylhistidine
hydrochloride; respiration; plethysmograph
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