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1 Division of Physiology, Department of Medicine, University of California, San Diego, La Jolla 92093; and 2 Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, California 92350
Exercise-induced arterial
hypoxemia (EIAH) has been reported in male athletes, particularly
during fast-increment treadmill exercise protocols. Recent reports
suggest a higher incidence in women. We hypothesized that 1-min
incremental (fast) running (R) protocols would result in a lower
arterial PO2 (PaO2) than 5-min
increment protocols (slow) or cycling exercise (C) and that women would
experience greater EIAH than previously reported for men. Arterial
blood gases, cardiac output, and metabolic data were obtained in 17 active women [mean maximal O2 uptake
(
O2 max) = 51 ml · kg
1 · min1]. They were studied in
random order (C or R), with a fast
O2 max protocol. After recovery, the
women performed 5 min of exercise at 30, 60, and 90% of
O2 max (slow). One week later, the
other exercise mode (R or C) was similarly studied. There were no
significant differences in O2 max
between R and C. Pulmonary gas exchange was similar at rest, 30%, and
60% of O2 max. At 90% of
O2 max, PaO2 was lower
during R (mean ± SE = 94 ± 2 Torr) than during C
(105 ± 2 Torr, P < 0.0001), as was ventilation
(85.2 ± 3.8 vs. 98.2 ± 4.4 l/min BTPS,
P < 0.0001) and cardiac output (19.1 ± 0.6 vs.
21.1 ± 1.0 l/min, P < 0.001). Arterial
PCO2 (32.0 ± 0.5 vs. 30.0 ± 0.6 Torr,
P < 0.001) and alveolar-arterial O2 difference
(A-aDO2; 22 ± 2 vs. 16 ± 2 Torr,
P < 0.0001) were greater during R. PaO2
and A-aDO2 were similar between slow and fast.
Nadir PaO2 was 
80 Torr in four women (24%) but only
during fast-R. In all subjects, PaO2 at
O2 max was greater than the lower 95%
prediction limit calculated from available data in men
(n = 72 C and 38 R) for both R and C. These data
suggest intrinsic differences in gas exchange between R and C, due
to differences in ventilation and also efficiency of gas exchange. The
PaO2 responses to R and C exercise in our 17 subjects do not differ significantly from those previously observed in men.
arterial blood gases; normal subjects; maximal exercise; acetylene uptake
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