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J Appl Physiol 89: 445-457, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 2, 445-457, August 2000

Effects of inertial load and countermeasures on the distribution of pulmonary blood flow

Myron A. Chornuk1, Susan L. Bernard2, John W. Burns3, Robb W. Glenny1,2, Don D. Sheriff4, Scott E. Sinclair2, Nayak L. Polissar5, and Michael P. Hlastala1,2

1 Department of Physiology and Biophysics and 2 Department of Medicine, University of Washington, Seattle, Washington 98195; 3 Biodynamics and Protection Division, Air Force Research Laboratory, Brooks Air Force Base, Texas 78235; 4 Department of Exercise Science, University of Iowa, Iowa City, Iowa 52242; 5 The Mountain-Whisper-Light Statistical Consulting, Seattle, Washington 98112

We assessed the influence of cranial-to-caudal inertial force (+Gz) and the countermeasures of anti-G suit and positive pressure breathing during G (PBG), specifically during +Gz, on regional pulmonary blood flow distribution. Unanesthetized swine were exposed randomly to 0 Gz (resting), +3 Gz, +6 Gz, and +9 Gz, with and without anti-G suit and PBG with the use of the Air Force Research Laboratory centrifuge at Brooks Air Force Base (the gravitational force of the Earth, that is, the dorsal-to-ventral inertial force, was present for all runs). Fluorescent microspheres were injected into the pulmonary vasculature as a marker of regional pulmonary blood flow. Lungs were excised, dried, and diced into ~2-cm3 pieces, and the fluorescence of each piece was measured. As +Gz was increased from 0 to +3 Gz, blood flow shifted from cranial and hilar regions toward caudal and peripheral regions of the lung. This redistribution shifted back toward cranial and hilar regions as anti-G suit inflation pressure increased at +6 and +9 Gz. Perfusion heterogeneity increased with +Gz stress and decreased at the higher anti-G suit pressures. The distribution of pulmonary blood flow was not affected by PBG. ANOVA indicated anatomic structure as the major determinant of pulmonary blood flow.

pulmonary perfusion; spatial heterogeneity; extended coverage anti-G suit; acceleration


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