| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Prince of Wales Medical Research Institute and the University of New South Wales, Sydney 2031, Australia
Responses to transcranial magnetic stimulation in human subjects (n = 9) were studied during series of intermittent isometric maximal voluntary contractions (MVCs) of the elbow. Stimuli were given during MVCs in four fatigue protocols with different duty cycles. As maximal voluntary torque fell during each protocol, the torque increment evoked by cortical stimulation increased from ~1.5 to 7% of ongoing torque. Thus "supraspinal" fatigue developed in each protocol. The motor evoked potential (MEP) and silent period in the elbow flexor muscles also changed. The silent period lengthened by 20-75 ms (lowest to highest duty cycle protocol) and recovered significantly with a 5-s rest. The MEP increased in area by >50% in all protocols and recovered significantly with 10 s, but not 5 s, of rest. These changes are similar to those during sustained MVC. The central fatigue demonstrated by the torque increments evoked by the stimuli did not parallel the changes in the electromyogram responses. This suggests that part of the fatigue developed during intermittent exercise is "upstream" of the motor cortex.
transcranial magnetic stimulation; central fatigue; motor cortex; exercise
This article has been cited by other articles:
|
|
 |
|
  B. W. Hoffman, T. Oya, T. J. Carroll, and A. G. Cresswell Increases in corticospinal responsiveness during a sustained submaximal plantar flexion J Appl Physiol, July 1, 2009; 107(1): 112 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Burnley Estimation of critical torque using intermittent isometric maximal voluntary contractions of the quadriceps in humans J Appl Physiol, March 1, 2009; 106(3): 975 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schmitt, C. DelloRusso, and R. F. Fregosi Force-EMG Changes During Sustained Contractions of a Human Upper Airway Muscle J Neurophysiol, February 1, 2009; 101(2): 558 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Sidhu, D. J. Bentley, and T. J. Carroll Locomotor exercise induces long-lasting impairments in the capacity of the human motor cortex to voluntarily activate knee extensor muscles J Appl Physiol, February 1, 2009; 106(2): 556 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Hunter, G. Todd, J. E. Butler, S. C. Gandevia, and J. L. Taylor Recovery from supraspinal fatigue is slowed in old adults after fatiguing maximal isometric contractions J Appl Physiol, October 1, 2008; 105(4): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Post, S. Bayrak, D. Kernell, and I. Zijdewind Contralateral muscle activity and fatigue in the human first dorsal interosseous muscle J Appl Physiol, July 1, 2008; 105(1): 70 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Levenez, S. J. Garland, M. Klass, and J. Duchateau Cortical and Spinal Modulation of Antagonist Coactivation During a Submaximal Fatiguing Contraction in Humans J Neurophysiol, February 1, 2008; 99(2): 554 - 563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Taylor and S. C. Gandevia A comparison of central aspects of fatigue in submaximal and maximal voluntary contractions J Appl Physiol, February 1, 2008; 104(2): 542 - 550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mendez-Villanueva, J. Fernandez-Fernandez, and D. Bishop Exercise-induced homeostatic perturbations provoked by singles tennis match play with reference to development of fatigue Br. J. Sports Med., November 1, 2007; 41(11): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Smith, P. G. Martin, S. C. Gandevia, and J. L. Taylor Sustained contraction at very low forces produces prominent supraspinal fatigue in human elbow flexor muscles J Appl Physiol, August 1, 2007; 103(2): 560 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Todd, J. L. Taylor, J. E. Butler, P. G. Martin, R. B. Gorman, and S. C. Gandevia Use of motor cortex stimulation to measure simultaneously the changes in dynamic muscle properties and voluntary activation in human muscles J Appl Physiol, May 1, 2007; 102(5): 1756 - 1766. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Martin, S. C. Gandevia, and J. L. Taylor Muscle fatigue changes cutaneous suppression of propriospinal drive to human upper limb muscles J. Physiol., April 1, 2007; 580(1): 211 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Z. Ross, N. Middleton, R. Shave, K. George, and A. Nowicky Human, Environmental & Exercise: Corticomotor excitability contributes to neuromuscular fatigue following marathon running in man Exp Physiol, March 1, 2007; 92(2): 417 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Racinais, O. Girard, J. P. Micallef, and S. Perrey Failed Excitability of Spinal Motoneurons Induced by Prolonged Running Exercise J Neurophysiol, January 1, 2007; 97(1): 596 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Hunter, J. E. Butler, G. Todd, S. C. Gandevia, and J. L. Taylor Supraspinal fatigue does not explain the sex difference in muscle fatigue of maximal contractions J Appl Physiol, October 1, 2006; 101(4): 1036 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Martin Can supraspinal/central fatigue explain the lesser muscle endurance of men compared with women? J Appl Physiol, October 1, 2006; 101(4): 1015 - 1016. [Full Text] [PDF]
|
|
|
|
|
|
S. C. Gandevia and J. L. Taylor Supraspinal fatigue: the effects of caffeine on human muscle performance J Appl Physiol, June 1, 2006; 100(6): 1749 - 1750. [Full Text] [PDF]
|
|
|
|
|
|
J. M. Kalmar and E. Cafarelli Central excitability does not limit postfatigue voluntary activation of quadriceps femoris J Appl Physiol, June 1, 2006; 100(6): 1757 - 1764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sogaard, S. C. Gandevia, G. Todd, N. T. Petersen, and J. L. Taylor The effect of sustained low-intensity contractions on supraspinal fatigue in human elbow flexor muscles J. Physiol., June 1, 2006; 573(2): 511 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Babault, K. Desbrosses, M.-S. Fabre, A. Michaut, and M. Pousson Neuromuscular fatigue development during maximal concentric and isometric knee extensions J Appl Physiol, March 1, 2006; 100(3): 780 - 785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Prasartwuth, J. L Taylor, and S. C Gandevia Maximal force, voluntary activation and muscle soreness after eccentric damage to human elbow flexor muscles J. Physiol., August 15, 2005; 567(1): 337 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Todd, J. E Butler, J. L Taylor, and S. C Gandevia Hyperthermia: a failure of the motor cortex and the muscle J. Physiol., March 1, 2005; 563(2): 621 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A St Clair Gibson and T D Noakes Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans Br. J. Sports Med., December 1, 2004; 38(6): 797 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Todd, J. L. Taylor, and S. C. Gandevia Reproducible measurement of voluntary activation of human elbow flexors with motor cortical stimulation J Appl Physiol, July 1, 2004; 97(1): 236 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Nordlund, A. Thorstensson, and A. G. Cresswell Central and peripheral contributions to fatigue in relation to level of activation during repeated maximal voluntary isometric plantar flexions J Appl Physiol, January 1, 2004; 96(1): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Butler, J. L. Taylor, and S. C. Gandevia Responses of Human Motoneurons to Corticospinal Stimulation during Maximal Voluntary Contractions and Ischemia J. Neurosci., November 12, 2003; 23(32): 10224 - 10230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Todd, J. L Taylor, and S C Gandevia Measurement of voluntary activation of fresh and fatigued human muscles using transcranial magnetic stimulation J. Physiol., September 1, 2003; 551(2): 661 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Andersen, B. Westlund, and C. Krarup Failure of activation of spinal motoneurones after muscle fatigue in healthy subjects studied by transcranial magnetic stimulation J. Physiol., August 15, 2003; 551(1): 345 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Z. Liu, Z. Y. Shan, L. D. Zhang, V. Sahgal, R. W. Brown, and G. H. Yue Human Brain Activation During Sustained and Intermittent Submaximal Fatigue Muscle Contractions: An fMRI Study J Neurophysiol, July 1, 2003; 90(1): 300 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Gandevia Spinal and Supraspinal Factors in Human Muscle Fatigue Physiol Rev, October 1, 2001; 81(4): 1725 - 1789. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
