Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 89: 228-234, 2000;
8750-7587/00 $5.00
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Vol. 89, Issue 1, 228-234, July 2000

Mechanical dissociation of bronchi from parenchyma in the immature piglet lung

Anthony L. Mansell1, Allison L. McAteer1, and Eben H. Oldmixon2

Departments of Pediatrics and Medicine, Brown University, 1 Rhode Island Hospital and 2 Memorial Hospital, Providence, Rhode Island 02902

Previous studies of isolated piglet lungs suggested that local distending forces around bronchi might be relatively weak before postnatal growth and maturation. The present study used tantalum bronchograms to compare pressure-diameter relationships of bronchi in situ and after excision from the parenchyma in immature (3- to 7-day-old) and mature (3-mo-old) piglets. The mature group reproduced behavior that is well established in mature lungs from other species; i.e., bronchial diameters maintained a constant relationship to the parenchyma as the lungs were deflated from maximum to minimum volume. In sharp contrast, diameters failed to change until the immature lungs were deflated to <5 cmH2O transpulmonary pressure. Total percent change in bronchial diameter was then only 24% in the immature lungs compared with 47% in the mature lungs (P < 0.002). Total elastances of mature generation 3-8 bronchi did not change when they were excised from the parenchyma. However, in the same generations of immature bronchi, total elastances were lower after than before (1.06 vs. 1.60 cmH2O/%, P < 0.05) excision from the parenchyma. Elastances of the excised immature and mature bronchi were then the same (1.06 vs. 1.03 cmH2O/%, not significant). Because elastic moduli of the lung parenchyma are also similar in the two age groups, it was concluded that local features of airway-parenchyma coupling limited the generation of local parenchymal recoil around bronchi in the immature lungs.

lung growth; airway-parenchyma interdependence; bronchograms


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