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Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001
Under anesthesia, inactivation of
the retrotrapezoid nucleus (RTN) region markedly inhibits breathing and
chemoreception. In conscious rats, we dialyzed muscimol for 30 min to
inhibit neurons of the RTN region reversibly. Dialysis of artificial
cerebrospinal fluid had no effect. Muscimol (1 or 10 mM) significantly
decreased tidal volume (VT) (by 16-17%) within 15 min. VT remained decreased for 50 min or more, with
recovery by 90 min. Ventilation (
E) decreased
significantly (by 15-20%) within 15 min and then returned to
baseline within 40 min as a result of an increase in frequency. This,
we suggest, is a compensatory physiological response to the reduced
VT. Oxygen consumption was unchanged. In response to 7%
CO2 in the 1 mM group, absolute E and
change in E were significantly reduced (by
19-22%). In the 10 mM group, the response to dialysis included a
time-related increase in frequency and decrease in body temperature,
which may reflect greater spread of muscimol. In the awake rat, the RTN
region provides a portion of the tonic drive to breathe, as well as a
portion of the response to hypercapnia.
control of breathing; GABAA receptors; rostral ventrolateral medulla; central chemoreceptors; hypoventilation
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