| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland 21205; and 2 Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44109
Acutely lowering ambient
O2 tension increases ventilation in many mammalian species,
including humans and mice.
Inheritance patterns among
kinships and between mouse strains suggest that a robust genetic
influence determines individual hypoxic ventilatory responses (HVR).
Here, we tested specific genetic hypotheses to describe the inheritance
patterns of HVR phenotypes among two inbred mouse strains and their
segregant and nonsegregant progeny. Using whole body plethysmography,
we assessed the magnitude and pattern of ventilation in C3H/HeJ (C3)
and C57BL/6J (B6) progenitor strains at baseline and during acute
(3-5 min) hypoxic [mild hypercapnic hypoxia, inspired
O2 fraction
(FIO2) = 0.10] and normoxic (mild hypercapnic normoxia,
FIO2 = 0.21) inspirate
challenges in mild hypercapnia (inspired CO2
fraction = 0.03). First- and second-filial generations and two
backcross progeny were also studied to assess response distributions of
HVR phenotypes relative to the parental strains. Although the
minute ventilation (
E) during hypoxia
was comparable between the parental strains, breathing frequency
(f) and tidal volume were significantly different; C3 mice
demonstrated a slow, deep HVR relative to a rapid, shallow phenotype of
B6 mice. The HVR profile in B6C3F1/J mice suggested that
this offspring class represented a third phenotype, distinguishable from the parental strains. The distribution of HVR among
backcross and intercross offspring suggested that the inheritance
patterns for f and E during
mild hypercapnic hypoxia are consistent with models that
incorporate two genetic determinants. These results further suggest
that the quantitative genetic expression of alleles derived from C3 and
B6 parental strains interact to significantly attenuate individual HVR
in the first- and second-filial generations. In conclusion, the genetic
control of HVR in this model was shown to exhibit a relatively simple
genetic basis in terms of respiratory timing characteristics.
C3H/HeJ; C57BL/6J; hypoventilation; hypercapnic ventilation; segregation analysis
This article has been cited by other articles:
|
|
 |
|
  M. R. Dwinell, H. V. Forster, J. Petersen, A. Rider, M. P. Kunert, A. W. Cowley Jr., and H. J. Jacob Genetic determinants on rat chromosome 6 modulate variation in the hypercapnic ventilatory response using consomic strains J Appl Physiol, May 1, 2005; 98(5): 1630 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Izumizaki, M. Pokorski, and I. Homma Role of the carotid bodies in chemosensory ventilatory responses in the anesthetized mouse J Appl Physiol, October 1, 2004; 97(4): 1401 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley and K. W. Broman Interactions in hypoxic and hypercapnic breathing are genetically linked to mouse chromosomes 1 and 5 J Appl Physiol, July 1, 2004; 97(1): 77 - 84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Groeben, S. Meier, C. G. Tankersley, W. Mitzner, and R. H. Brown Influence of volatile anaesthetics on hypercapnoeic ventilatory responses in mice with blunted respiratory drive{dagger} Br. J. Anaesth., May 1, 2004; 92(5): 697 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Groeben, S. Meier, C. G. Tankersley, W. Mitzner, and R. H. Brown Heritable differences in respiratory drive and breathing pattern in mice during anaesthesia and emergence{dagger} Br. J. Anaesth., October 1, 2003; 91(4): 541 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamaguchi, A. Balbir, B. Schofield, J. Coram, C. G. Tankersley, R. S. Fitzgerald, C. P. O'Donnell, and M. Shirahata Structural and functional differences of the carotid body between DBA/2J and A/J strains of mice J Appl Physiol, April 1, 2003; 94(4): 1536 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Hodges, H. V. Forster, P. E. Papanek, M. R. Dwinell, and G. E. Hogan Ventilatory phenotypes among four strains of adult rats J Appl Physiol, September 1, 2002; 93(3): 974 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Han, S. Subramanian, E. R. Price, J. Nadeau, and K. P. Strohl Periodic breathing in the mouse J Appl Physiol, March 1, 2002; 92(3): 1133 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, M. A. Haxhiu, and E. B. Gauda Differential CO2-induced c-fos gene expression in the nucleus tractus solitarii of inbred mouse strains J Appl Physiol, March 1, 2002; 92(3): 1277 - 1284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley, R. Irizarry, S. Flanders, and R. Rabold Functional Genomics of Sleep and Circadian Rhythm: Selected Contribution: Circadian rhythm variation in activity, body temperature, and heart rate between C3H/HeJ and C57BL/6J inbred strains J Appl Physiol, February 1, 2002; 92(2): 870 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakano, S.-D. Lee, and G. A. Farkas Dopaminergic modulation of ventilation in obese Zucker rats J Appl Physiol, January 1, 2002; 92(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Renolleau, S. Dauger, F. Autret, G. Vardon, C. Gaultier, and J. Gallego Maturation of baseline breathing and of hypercapnic and hypoxic ventilatory responses in newborn mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1746 - R1753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Tankersley Physiological and Genomic Consequences of Intermittent Hypoxia: Selected Contribution: Variation in acute hypoxic ventilatory response is linked to mouse chromosome 9 J Appl Physiol, April 1, 2001; 90(4): 1615 - 1622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. FULLER, T. L. BAKER, M. BEHAN, and G. S. MITCHELL Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat Physiol Genomics, January 19, 2001; 4(3): 175 - 181. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
