Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 2296-2301, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (26)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Donnelly, D. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Donnelly, D. F.
Vol. 88, Issue 6, 2296-2301, June 2000

INVITED REVIEW
Developmental aspects of oxygen sensing by the carotid body

David F. Donnelly

Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520

The carotid body chemoreceptors, the major hypoxia sensory organs for the respiratory system, undergo a significant increase in their hypoxia responsiveness in the postnatal period. This is manifest by a higher level of afferent nerve activity for a given level of arterial oxygen tension. The mechanism for the enhanced sensitivity is unresolved, but most work has focused on the glomus cell, a secretory cell apposed to the afferent nerve ending and believed to be the site of hypoxia transduction. The glomus cell secretory response to hypoxia increases postnatally, and this is correlated with an enhanced calcium rise in response to hypoxia and an increase in oxygen-sensitive potassium currents. These changes are sensitive to the level of hypoxia in the postnatal period, and significant impairment of organ function is observed with postnatal hypoxia as well as postnatal hyperoxia. Although many questions remain, especially with regard to the coupling of glomus cells to nerve endings, the use of cellular and molecular techniques should offer resolution in the near future.

afferents; receptor properties; development


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Pawar, Y.-J. Peng, F. J. Jacono, and N. R. Prabhakar
Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia
J Appl Physiol, May 1, 2008; 104(5): 1287 - 1294.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Lofaso, S. Dauger, B. Matrot, G. Vardon, C. Gaultier, and J. Gallego
Inhibitory effects of repeated hyperoxia on breathing in newborn mice
Eur. Respir. J., January 1, 2007; 29(1): 18 - 24.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
E. K. Weir, J. Lopez-Barneo, K. J. Buckler, and S. L. Archer
Acute Oxygen-Sensing Mechanisms.
N. Engl. J. Med., November 10, 2005; 353(19): 2042 - 2055.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. L. Carroll, K. M. Boyle, M. J. Wasicko, and L. M. Sterni
Dopamine D2 receptor modulation of carotid body type 1 cell intracellular calcium in developing rats
Am J Physiol Lung Cell Mol Physiol, May 1, 2005; 288(5): L910 - L916.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
M. G. Jonz and C. A. Nurse
Development of oxygen sensing in the gills of zebrafish
J. Exp. Biol., April 15, 2005; 208(8): 1537 - 1549.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-J. Peng, J. Rennison, and N. R. Prabhakar
Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups
J Appl Physiol, November 1, 2004; 97(5): 2020 - 2025.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. R. Prabhakar and Y.-J. Peng
Peripheral chemoreceptors in health and disease
J Appl Physiol, January 1, 2004; 96(1): 359 - 366.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis, E. B. Olson Jr., E. H. Vidruk, G. E. Bisgard, and G. S. Mitchell
Level and duration of developmental hyperoxia influence impairment of hypoxic phrenic responses in rats
J Appl Physiol, October 1, 2003; 95(4): 1550 - 1559.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Izumizaki, M. Tamaki, Y.-i. Suzuki, M. Iwase, T. Shirasawa, H. Kimura, and I. Homma
The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R747 - R753.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Carroll
Plasticity in Respiratory Motor Control: Invited Review: Developmental plasticity in respiratory control
J Appl Physiol, January 1, 2003; 94(1): 375 - 389.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis, E. B. Olson Jr., and G. S. Mitchell
Critical developmental period for hyperoxia-induced blunting of hypoxic phrenic responses in rats
J Appl Physiol, March 1, 2002; 92(3): 1013 - 1018.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. B. Gauda, R. Cooper, P. K. Akins, and G. Wu
Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion
J Appl Physiol, November 1, 2001; 91(5): 2157 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. R. Prabhakar
Oxygen sensing by the carotid body chemoreceptors
J Appl Physiol, June 1, 2000; 88(6): 2287 - 2295.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online