Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 88: 2269-2278, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 6, 2269-2278, June 2000

Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse

Scott E. Sinclair1, Steve McKinney1, Robb W. Glenny1,2, Susan L. Bernard1, and Michael P. Hlastala1,2

Departments of 1 Medicine and 2 Physiology and Biophysics, University of Washington, Seattle, Washington 98195-6522

We determined the changes in fractal dimensions and spatial correlations of regional pulmonary blood flow with increasing exercise in race horses (n = 4) by using 15-µm fluorescent microspheres. Fluorescence was measured to quantitate regional blood to 1.3-cm3 samples (n = 1,621-2,503). Perfusion distributions were characterized with fractal dimensions (a measure of spatial variability) and spatial correlations. On average, the fractal dimension decreased with exercise (trot 1.216 to gallop 1.173; P < 0.05) despite a variable fractal dimension at rest. Spatial correlation of flow to neighboring pieces increased with exercise (trot 0.57 ± 0.074 to gallop 0.73 ± 0.051) and was inversely correlated with fractal dimension, indicating better spatial correlation as blood flow distribution becomes more uniform. This is the first study to document a change in fractal dimension as a result of increasing pulmonary blood flow. Spatial differences in response to vasoregulatory mediators may play a role in this phenomenon.

fluorescent microspheres; cardiac output


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