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J Appl Physiol 88: 2240-2245, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 6, 2240-2245, June 2000

Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training

Thomas H. Reynolds IV1,2, Joseph T. Brozinick Jr.1, Lisa M. Larkin2, and Samuel W. Cushman1

1 Experimental Diabetes, Metabolism, and Nutrition Section, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; and 2 Division of Geriatric Medicine, University of Michigan, Ann Arbor, Michigan 48109

The purpose of the present study was to examine the effect of detraining on the glucose transport system after short-term swim training (5 days), long-term swim training (5 wk), and treadmill run training (5 wk). Skeletal muscles were isolated from female Wistar rats at 24 or 48 h posttraining. SST produces a 48% increase in GLUT-4 mRNA, a 30% increase in GLUT-4 protein, and a 60% increase in insulin-stimulated glucose transport activity at 24 h posttraining but not at 48 h posttraining. Similar to SST, long-term swim training produces a 60% increase in GLUT-4 mRNA and a 30% increase in GLUT-4 protein content at 24 h posttraining but not at 48 h posttraining. Finally, treadmill run training produces a transient 35% increase in GLUT-4 protein content that is completely reversed at 48 h after the last bout of exercise. These results demonstrate that the increase in GLUT-4 mRNA and GLUT-4 protein occurs during the first week of exercise training and is rapidly lost after training cessation. We believe that the transient enhancement in GLUT-4 protein after exercise training is due to a short GLUT-4 half-life, a process that is primarily regulated by pretranslational mechanisms.

glucose transporters; detraining; glucose metabolism; training cessation; insulin action


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