Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 2192-2198, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Held, H.-D.
Right arrow Articles by Uhlig, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Held, H.-D.
Right arrow Articles by Uhlig, S.
Vol. 88, Issue 6, 2192-2198, June 2000

Basal lung mechanics and airway and pulmonary vascular responsiveness in different inbred mouse strains

Heinz-Dieter Held and Stefan Uhlig

Division of Pulmonary Pharmacology, Research Center Borstel, 23845 Borstel, Germany

Little is known about interstrain variations in baseline lung functions or smooth muscle contractility in murine lungs. We therefore examined basal lung mechanics and airway, as well as vascular reactivity to methacholine, thromboxane (using U-46619), and endothelin-1 (ET-1), A/J, AKR, BALB/c, C3H/HeN, C57BL/6, and SCID mice. All experiments were performed with isolated perfused mouse lungs. Except AKR mice (which were excluded from further analysis), all other strains showed stable pulmonary compliance, pulmonary resistance, and pulmonary arterial pressure within a control period of 45 min. Among these strains, C3H/HeN mice exhibited higher dynamic pulmonary compliance and lower pulmonary resistance, whereas SCID mice had higher baseline pulmonary resistance than the other strains. Concentration-response experiments with methacholine showed a lower airway reactivity for C57BL/6 mice compared with the other strains. Perfusion with 1 µM U-46619 or 100 nM ET-1 revealed a similar pattern: the agonist-inducible broncho- and vasoconstriction was lower in C57BL/6 mice than in all other strains, whereas it tended to be higher in SCID mice. The present study demonstrates a correlation between airway and vascular responsiveness in all tested strains. SCID mice are hyperreactive, whereas C57BL/6 mice are hyporeactive, to smooth muscle constrictors. Lung mechanics, as well as airway and vascular responsiveness, appear to be genetically controlled.

perfused mouse lung; hyperresponsiveness; genetic control; endothelin; thromboxane


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Witzenrath, B. Ahrens, S. M. Kube, A. Braun, H. G. Hoymann, A. C. Hocke, S. Rosseau, N. Suttorp, E. Hamelmann, and H. Schutte
Detection of allergen-induced airway hyperresponsiveness in isolated mouse lungs
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L466 - L472.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. B. T. Anh, P. Faisca, and D. J.-M. Desmecht
Differential resistance/susceptibility patterns to pneumovirus infection among inbred mouse strains
Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L426 - L435.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Witzenrath, B. Ahrens, S. M. Kube, A. C. Hocke, S. Rosseau, E. Hamelmann, N. Suttorp, and H. Schutte
Allergic lung inflammation induces pulmonary vascular hyperresponsiveness
Eur. Respir. J., August 1, 2006; 28(2): 370 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Koch, M. Witzenrath, C. Reuter, M. Herma, H. Schutte, N. Suttorp, H. Collins, and S. H. E. Kaufmann
Role of Local Pulmonary IFN-{gamma} Expression in Murine Allergic Airway Inflammation
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 211 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
P. Faisca, D. B. T. Anh, and D. J.-M. Desmecht
Sendai virus-induced alterations in lung structure/function correlate with viral loads and reveal a wide resistance/susceptibility spectrum among mouse strains
Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L777 - L787.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Hasegawa, K. F. Wagner, D. Karp, D. Li, J. Shibata, M. Heringlake, L. Bahlmann, R. Depping, J. Fandrey, P. Schmucker, et al.
Altered Pulmonary Vascular Reactivity in Mice with Excessive Erythrocytosis
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 829 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
U. Uhlig, H. Fehrenbach, R. A. Lachmann, T. Goldmann, B. Lachmann, E. Vollmer, and S. Uhlig
Phosphoinositide 3-OH Kinase Inhibition Prevents Ventilation-induced Lung Cell Activation
Am. J. Respir. Crit. Care Med., January 15, 2004; 169(2): 201 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
U. Uhlig, J.J. Haitsma, T. Goldmann, D.L. Poelma, B. Lachmann, and S. Uhlig
Ventilation-induced activation of the mitogen-activated protein kinase pathway
Eur. Respir. J., October 1, 2002; 20(4): 946 - 956.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. J. A. Janssen and J. F. M. Smits
Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1545 - R1564.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Ehlers, J. Benini, H.-D. Held, C. Roeck, G. Alber, and S. Uhlig
{alpha}{beta} T Cell Receptor-positive Cells and Interferon-{gamma}, but not Inducible Nitric Oxide Synthase, Are Critical for Granuloma Necrosis in a Mouse Model of Mycobacteria-induced Pulmonary Immunopathology
J. Exp. Med., December 17, 2001; 194(12): 1847 - 1859.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-D. HELD, S. BOETTCHER, L. HAMANN, and S. UHLIG
Ventilation-Induced Chemokine and Cytokine Release Is Associated with Activation of Nuclear Factor-{kappa}B and Is Blocked by Steroids
Am. J. Respir. Crit. Care Med., March 1, 2001; 163(3): 711 - 716.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online