Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 2008-2014, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, L. R.
Right arrow Articles by Laughlin, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, L. R.
Right arrow Articles by Laughlin, M. H.
Vol. 88, Issue 6, 2008-2014, June 2000

Chronic exercise training does not alter pulmonary vasorelaxation in normal pigs

Lynelle R. Johnson and M. Harold Laughlin

Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri 65211

Exercise training increases acetylcholine-induced pulmonary vasorelaxation in pigs with coronary occlusion. The present study tested the hypothesis that chronic exercise training enhances endothelium-mediated vasorelaxation in pulmonary arteries from normal pigs. Yucatan miniswine exercised for 16 wk on a treadmill (Ex); control pigs (Sed) remained in pens. Pulmonary artery rings (2- to 3-mm OD) were studied using standard isometric techniques. Contractile responses to 80 mM KCl and norepinephrine (NE) were determined. Vessels were constricted with levels of NE that resulted in half-maximal contraction to examine endothelium-dependent relaxation to ACh and endothelium-independent relaxation to sodium nitroprusside in the presence and absence of nitric oxide synthase inhibition, cyclooxygenase inhibition, and endothelial denudation. Arteries from Ex pigs developed increased contraction to 80 mM KCl, but the response to NE did not differ between groups. Endothelium-dependent and endothelium-independent responses did not differ between Sed and Ex in the presence or absence of pharmacological inhibitors or denudation. We conclude that chronic exercise training does not alter endothelium-dependent or endothelium-independent vasorelaxation responses of pulmonary arteries from normal pigs.

pulmonary circulation; porcine; voltage-gated calcium channels; nitric oxide synthase


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, S. C. Newcomer, and S. B. Bender
Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype
J Appl Physiol, March 1, 2008; 104(3): 588 - 600.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. J Green, A. Maiorana, G. O'Driscoll, and R. Taylor
Effect of exercise training on endothelium-derived nitric oxide function in humans
J. Physiol., November 15, 2004; 561(1): 1 - 25.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Laughlin, L. J. Rubin, J. W. E. Rush, E. M. Price, W. G. Schrage, and C. R. Woodman
Short-term training enhances endothelium-dependent dilation of coronary arteries, not arterioles
J Appl Physiol, January 1, 2003; 94(1): 234 - 244.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. K. Henderson, R. L. Clancy, and N. C. Gonzalez
Living and training in moderate hypoxia does not improve {V}O2 max more than living and training in normoxia
J Appl Physiol, June 1, 2001; 90(6): 2057 - 2062.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. R. Johnson, J. W. E. Rush, J. R. Turk, E. M. Price, and M. H. Laughlin
Short-term exercise training increases ACh-induced relaxation and eNOS protein in porcine pulmonary arteries
J Appl Physiol, March 1, 2001; 90(3): 1102 - 1110.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online