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J Appl Physiol 88: 1983-1988, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 6, 1983-1988, June 2000

PGH2-TxA2-receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension

Hideyuki Suzuki, Hiroyuki Ikezaki, Dennis Hong, and Israel Rubinstein

Department of Medicine, University of Illinois at Chicago, and West Side Department of Veterans Affairs Medical Center, Chicago, Illinois 60612

The purpose of this study was to determine whether activation of prostaglandin H2-thromboxane A2 (PGH2-TxA2) receptors impedes vasodilation in the in situ peripheral microcirculation of spontaneously hypertensive hamsters, a new rodent model of high-renin genetic hypertension. Using intravital microscopy, we found that vasodilation elicited by suffusion of acetylcholine and vasoactive intestinal peptide (VIP), two neurotransmitters localized in perivascular nerves in the peripheral circulation, on the in situ cheek pouch was significantly attenuated in spontaneously hypertensive hamsters relative to age- and genetically matched normotensive hamsters (P < 0.05). However, nitroglycerin-induced vasodilation was similar in both groups. Pretreatment with SQ-29548, a selective and potent PGH2-TxA2-receptor antagonist, restored acetylcholine- and VIP-induced vasodilation in spontaneously hypertensive hamsters. SQ-29548 had no significant effects on resting arteriolar diameter and on nitroglycerin-induced vasodilation in both groups. SQ-29548 slightly but significantly potentiated VIP- but not acetylcholine-induced vasodilation in normotensive hamsters. Collectively, these data indicate that activation of PGH2-TxA2 receptors impedes agonist-induced vasodilation in the in situ cheek pouch of spontaneously hypertensive hamsters. We suggest that this model is suitable for studying the role of prostanoids in mediating vasomotor dysfunction observed in genetic hypertension.

essential hypertension; microcirculation; vasomotor tone; nitric oxide; acetylcholine; vasoactive intestinal peptide; nitroglycerin; prostaglandins; SQ-29548


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