Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1933-1942, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gerbino, A. J.
Right arrow Articles by Glenny, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gerbino, A. J.
Right arrow Articles by Glenny, R. W.
Vol. 88, Issue 6, 1933-1942, June 2000

Correlation between ventilation and perfusion determines VA/Q heterogeneity in endotoxemia

Anthony J. Gerbino1, Steven McKinney1, and Robb W. Glenny1,2

Departments of 1 Medicine and 2 Physiology and Biophysics, University of Washington, Seattle, Washington 98195

Endotoxin increases ventilation-to-perfusion ratio (VA/Q) heterogeneity in the lung, but the precise changes in alveolar ventilation (VA) and perfusion that lead to VA/Q heterogeneity are unknown. The purpose of this study was to determine how endotoxin affects the distributions of ventilation and perfusion and the impact of these changes on VA/Q heterogeneity. Seven anesthetized, mechanically ventilated juvenile pigs were given E. coli endotoxin intravenously, and regional ventilation and perfusion were measured simultaneously by using aerosolized and injected fluorescent microspheres. Endotoxemia significantly decreased the correlation between regional ventilation and perfusion, increased perfusion heterogeneity, and redistributed perfusion between lung regions. In contrast, ventilation heterogeneity did not change, and redistribution of ventilation was modest. The decrease in correlation between regional ventilation and perfusion was responsible for significantly more VA/Q heterogeneity than were changes in ventilation or perfusion heterogeneity. We conclude that VA/Q heterogeneity increases during endotoxemia primarily as a result of the decrease in correlation between regional ventilation and perfusion, which is in turn determined primarily by changes in perfusion.

acute lung injury; airway; breathing; gas exchange; inert gas; ventilation-perfusion heterogeneity


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
H. T. Robertson and M. P. Hlastala
Microsphere maps of regional blood flow and regional ventilation
J Appl Physiol, March 1, 2007; 102(3): 1265 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. A. Altemeier, S. McKinney, M. Krueger, and R. W. Glenny
Effect of posture on regional gas exchange in pigs
J Appl Physiol, December 1, 2004; 97(6): 2104 - 2111.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Chang, S. J. Lai-Fook, K. B. Domino, C. Schimmel, J. Hildebrandt, H. T. Robertson, R. W. Glenny, and M. P. Hlastala
Spatial distribution of ventilation and perfusion in anesthetized dogs in lateral postures
J Appl Physiol, February 1, 2002; 92(2): 745 - 762.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. J. Gerbino and R. W. Glenny
Lung albumin accumulation is spatially heterogeneous but not correlated with regional pulmonary perfusion
J Appl Physiol, January 1, 2002; 92(1): 279 - 287.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. J. Gerbino, W. A. Altemeier, C. Schimmel, and R. W. Glenny
Endotoxemia increases relative perfusion to dorsal-caudal lung regions
J Appl Physiol, April 1, 2001; 90(4): 1508 - 1515.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online