Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1840-1852, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Curran, A. K.
Right arrow Articles by Smith, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Curran, A. K.
Right arrow Articles by Smith, C. A.
Vol. 88, Issue 5, 1840-1852, May 2000

Ventilatory responses to specific CNS hypoxia in sleeping dogs

Aidan K. Curran, Joshua R. Rodman, Peter R. Eastwood, Kathleen S. Henderson, Jerome A. Dempsey, and Curtis A. Smith

The John Rankin Laboratory of Pulmonary Medicine, Department of Preventive Medicine, University of Wisconsin, Madison, Wisconsin 53705

Our study was concerned with the effect of brain hypoxia on cardiorespiratory control in the sleeping dog. Eleven unanesthetized dogs were studied; seven were prepared for vascular isolation and extracorporeal perfusion of the carotid body to assess the effects of systemic [and, therefore, central nervous system (CNS)] hypoxia (arterial PO2 = 52, 45, and 38 Torr) in the presence of a normocapnic, normoxic, and normohydric carotid body during non-rapid eye movement sleep. A lack of ventilatory response to systemic boluses of sodium cyanide during carotid body perfusion demonstrated isolation of the perfused carotid body and lack of other significant peripheral chemosensitivity. Four additional dogs were carotid body denervated and exposed to whole body hypoxia for comparison. In the sleeping dog with an intact and perfused carotid body exposed to specific CNS hypoxia, we found the following. 1) CNS hypoxia for 5-25 min resulted in modest but significant hyperventilation and hypocapnia (minute ventilation increased 29 ± 7% at arterial PO2 = 38 Torr); carotid body-denervated dogs showed no ventilatory response to hypoxia. 2) The hyperventilation was caused by increased breathing frequency. 3) The hyperventilatory response developed rapidly (<30 s). 4) Most dogs maintained hyperventilation for up to 25 min of hypoxic exposure. 5) There were no significant changes in blood pressure or heart rate. We conclude that specific CNS hypoxia, in the presence of an intact carotid body maintained normoxic and normocapnic, does not depress and usually stimulates breathing during non-rapid eye movement sleep. The rapidity of the response suggests a chemoreflex meditated by hypoxia-sensitive respiratory-related neurons in the CNS.

carotid body; hypoxic depression; chemoreceptors; hypocapnia


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. M. Blain, C. A. Smith, K. S. Henderson, and J. A. Dempsey
Contribution of the carotid body chemoreceptors to eupneic ventilation in the intact, unanesthetized dog
J Appl Physiol, May 1, 2009; 106(5): 1564 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. K. Stickland, B. J. Morgan, and J. A. Dempsey
Carotid chemoreceptor modulation of sympathetic vasoconstrictor outflow during exercise in healthy humans
J. Physiol., March 15, 2008; 586(6): 1743 - 1754.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, B. J. Chenuel, K. S. Henderson, and J. A. Dempsey
The apneic threshold during non-REM sleep in dogs: sensitivity of carotid body vs. central chemoreceptors
J Appl Physiol, August 1, 2007; 103(2): 578 - 586.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, J. R. Rodman, B. J. A. Chenuel, K. S. Henderson, and J. A. Dempsey
Response time and sensitivity of the ventilatory response to CO2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors
J Appl Physiol, January 1, 2006; 100(1): 13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. A. Dempsey
Crossing the apnoeic threshold: causes and consequences
Exp Physiol, January 1, 2005; 90(1): 13 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A Dempsey, C. A Smith, T. Przybylowski, B. Chenuel, A. Xie, H. Nakayama, and J. B Skatrud
The ventilatory responsiveness to CO2 below eupnoea as a determinant of ventilatory stability in sleep
J. Physiol., October 1, 2004; 560(1): 1 - 11.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Nakayama, C. A. Smith, J. R. Rodman, J. B. Skatrud, and J. A. Dempsey
Carotid body denervation eliminates apnea in response to transient hypocapnia
J Appl Physiol, January 1, 2003; 94(1): 155 - 164.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. W. Bavis and G. S. Mitchell
Plasticity in Respiratory Motor Control: Selected Contribution: Intermittent hypoxia induces phrenic long-term facilitation in carotid-denervated rats
J Appl Physiol, January 1, 2003; 94(1): 399 - 409.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Xie, J. B Skatrud, and J. A Dempsey
Effect of hypoxia on the hypopnoeic and apnoeic threshold for CO2 in sleeping humans
J. Physiol., August 15, 2001; 535(1): 269 - 278.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online