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J Appl Physiol 88: 1659-1671, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 5, 1659-1671, May 2000

Ventilation heterogeneity in excised lobes: effect of tidal volume

Michael J. Emery1, Jacob Hildebrandt1,2, and Michael P. Hlastala1,2

Departments of 1 Physiology and Biophysics and 2 Medicine, University of Washington, Seattle, Washington 98195

Although several factors are known to influence nonuniformity of ventilation, including lung mechanical properties (regional structure and compliance), external factors (chest wall, pleural pressure, heart), and ventilatory parameters (tidal and preinspiratory volume, flow rate), their relative contributions are poorly understood. We studied five excised, unperfused, canine right-middle lobes under varied levels of tidal volume (VT), thus eliminating many factors affecting heterogeneity. Multiple-breath washouts of N2 were analyzed for anatomic dead space volume (VDanat), nonuniformity of N2 washout, and nonuniformity between joined acinar regions vs. that occurring between larger joined regions. Approximately 80% of ventilation heterogeneity was found among joined acinar regions at resting levels of VT, but increasing VT reduced intra-acinar heterogeneity to about 25% of that found at resting levels. Increasing VT had essentially no effect on VDanat and heterogeneity among larger joined regions. The results indicate that the magnitude of VT is a major influence on the dominant intra-acinar component of ventilation heterogeneity and that VT effects on VDanat are likely due to perfusion and/or influences normally external to the lobar structure.

intraregional ventilation distribution; phase III slope; multiple breath inert-gas washout; normalized phase III slope


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