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1 Laboratoire de Physiologie Générale, Faculté des Sciences Nantes, 4322 Nantes Cedex 3; 2 Institut National de la Santé et de la Recherche Médicale U298, Centre Hospitalier Universitaire Angers, 49033 Angers Cedex, France; and 3 Unità di Farmacologia, Dipartimento Farmacobilogico, Università degli Studi di Bari, 70125 Bari, Italy
The purpose of the present work was to
see whether changes in rat soleus characteristics due to 3 wk of
hindlimb suspension could be modified by ciliary neurotrophic factor
(CNTF) treatment. Throughout the tail suspension period,
the cytokine was delivered by means of an osmotic pump (flow rate 16 µg · kg
1 · h1)
implanted under the hindlimb skin. In contrast to extensor digitorum longus, CNTF treatment was able to reduce unweighting-induced atrophy
in the soleus. Twitch and 146 mM potassium (K) tensions, measured in
small bundles of unloaded soleus, decreased by 48 and 40%,
respectively. Moreover, the time to peak tension and the time constant
of relaxation of the twitch were 48 and 54% faster, respectively, in
unloaded soleus than in normal muscle. On the contrary, twitch and 146 mM K contracture generated in CNTF-treated unloaded and normal soleus
were not different. CNTF receptor-
mRNA expression increased in
extensor digitorum longus and soleus unloaded nontreated muscles but
was similar in CNTF-treated unloaded muscles. The present results
demonstrate that exogenously provided CNTF could prevent functional
changes occurring in soleus innervated muscle subject to unweighting.
ciliary neurotrophic factor receptor-; mammalian skeletal
muscle; hindlimb unweighting
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