Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1581-1589, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhan, W.-Z.
Right arrow Articles by Sieck, G. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhan, W.-Z.
Right arrow Articles by Sieck, G. C.
Vol. 88, Issue 5, 1581-1589, May 2000

Regional differences in serotonergic input to canine parasternal intercostal motoneurons

Wen-Zhi Zhan1, Carlos B. Mantilla1, Phillip Zhan1, Asaf Bitton1, Y. S. Prakash1, Andre de Troyer3, and Gary C. Sieck1,2

Departments of 1 Anesthesiology and 2 Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905; and 3 Laboratory of Cardiorespiratory Physiology and Chest Service, Erasme University Hospital, Brussels School of Medicine, 1070 Brussels, Belgium

There is a mediolateral gradient in activation of the parasternal intercostal (PI) muscle during inspiration. In the present study, we tested the hypotheses that serotonergic [5-hydroxytryptamine (5-HT)] input from descending central drive and/or intrinsic size-related properties of PI motoneurons leads to the differential activation of PI muscles. In dogs, PI motoneurons innervating the medial and lateral regions of the PI muscles at the T3-T5 interspaces were retrogradely labeled by intramuscular injection of cholera toxin B subunit. After a 10-day survival period, PI motoneurons and 5-HT terminals were visualized by using immunohistochemistry and confocal imaging. There were no differences in motoneuron morphology among motoneurons innervating the medial and lateral regions of the PI muscle. However, the number of 5-HT terminals and the 5-HT terminal density (normalized for surface area) were greater in motoneurons innervating the medial region of the PI muscle compared with the lateral region. These results suggest that differences in distribution of 5-HT input may contribute to regional differences in PI muscle activation during inspiration and that differences in PI motoneuron recruitment do not relate to size.

respiratory muscles; biogenic amines; spinal cord; neuromodulation; immunohistochemistry; confocal microscopy


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. C. Gandevia, A. L. Hudson, R. B. Gorman, J. E. Butler, and A. De Troyer
Spatial distribution of inspiratory drive to the parasternal intercostal muscles in humans
J. Physiol., May 15, 2006; 573(1): 263 - 275.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. De Troyer, P. A. Kirkwood, and T. A. Wilson
Respiratory Action of the Intercostal Muscles
Physiol Rev, April 1, 2005; 85(2): 717 - 756.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online