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Vol. 88, Issue 5, 1571-1575, May 2000

No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status

Tuomo Rankinen¹, Bernd Wolfarth², Jean-Aimé Simoneau^,3, Dirk Maier-Lenz², Rainer Rauramaa⁴, Miguel A. Rivera⁵, Marcel R. Boulay³, Yvon C. Chagnon³, Louis Pérusse³, Joseph Keul², and Claude Bouchard¹

¹ Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808-4124; ² Department of Prevention, Rehabilitation, and Sports Medicine, University of Freiburg, 79106 Freiburg, Germany; ³ Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Québec G1K 7P4; Canada; ⁴ Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio, and Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, 70100 Kuopio, Finland; and ⁵ Department of Physiology and Department of Physical Medicine, Rehabilitation, and Sports Medicine, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936

Several studies have reported that the insertion (I) allele of the angiotensin-converting enzyme (ACE) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is more common in endurance athletes than in sedentary controls. We tested the latter hypothesis in a cohort of 192 male endurance athletes with maximal oxygen uptake 75 ml · kg¹ · min¹ and 189 sedentary male controls. The ACE ID polymorphism in intron 16 was typed with the three-primer polymerase chain reaction method. Both the genotype (P = 0.214) and allele (P = 0.095) frequencies were similar in the athletes and the controls. Further analyses in the athletes revealed no excess of the I allele among the athletes within the highest quartile (> 80 ml · kg¹ · min¹) or decile (>83 ml · kg¹ · min¹) of maximal oxygen uptake. These data from the GENATHLETE cohort do not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level.

genetics; sports; endurance performance; insertion/deletion

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 Deceased 27 August 1999.

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