Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 88: 1558-1564, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 5, 1558-1564, May 2000

Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products

P. J. M. van den Burg1, J. E. H. Hospers1, W. L. Mosterd1, B. N. Bouma2, and I. A. Huisveld1

1 Department of Medical Physiology and Sports Medicine and 2 Department of Hematology, University of Utrecht, 3508 TA Utrecht, The Netherlands

The influence of age on training-induced changes in resting and stimulated hemostatic potential was studied in three age categories (Cat I-III; 20-30 yr, 35-45 yr, and 50-60 yr, respectively) of sedentary men before and after 12 wk of training. Coagulation, fibrinolytic activity, and activation markers (reflecting fibrin formation and degradation) were determined. Physical conditioning resulted in a more pronounced increase in von Willebrand factor (vWF) and factor VIII clotting activity (FVIII:c) in Cat I and II and a more pronounced shortening of the activated partial thromboplastin time in all categories at maximal exertion and during recovery. Enhanced increases in tissue-type plasminogen activator (t-PA) antigen and activity and single-chain (sc) urokinase-type plasminogen activator (u-PA) at maximal exercise and 5 min of recovery were observed in all age groups after training. The effects on FVIII:c, vWF, and scu-PA were most pronounced in the youngest age group (Cat I). Increases in the marker of thrombin generation were highest in Cat III; no effect was seen on thrombin-antithrombin complex, plasmin-antiplasmin complex, and D-dimer in any of the age groups. We concluded that training enhances both coagulation and fibrinolytic potential during strenuous exercise. The effect on FVIII/vWF and t-PA/u-PA is most pronounced in younger individuals, whereas thrombin formation is most pronounced in older individuals.

activation markers; coagulation; fibrinolysis


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