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Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914
All organisms can sense O2 concentration and respond to hypoxia with adaptive changes in gene expression. The large body size of mammals necessitates the development of multiple complex physiological systems to ensure adequate O2 delivery to all cells under normal conditions. The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O2 homeostasis. HIF-1 is required for the establishment of key physiological systems during development and their subsequent utilization in fetal and postnatal life. HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies. Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders.
angiogenesis; glycolysis; ischemia; pulmonary hypertension; vascular endothelial growth factor; hypoxia-inducible factor 1
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E. Temes, S. Martin-Puig, B. Acosta-Iborra, M. C. Castellanos, M. Feijoo-Cuaresma, G. Olmos, J. Aragones, and M. O. Landazuri Activation of HIF-prolyl Hydroxylases by R59949, an Inhibitor of the Diacylglycerol Kinase J. Biol. Chem., June 24, 2005; 280(25): 24238 - 24244. [Abstract] [Full Text] [PDF]
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 A. Grimberg, C. M. Coleman, T. F. Burns, B. P. Himelstein, C. J. Koch, P. Cohen, and W. S. El-Deiry p53-Dependent and p53-Independent Induction of Insulin-Like Growth Factor Binding Protein-3 by Deoxyribonucleic Acid Damage and Hypoxia J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3568 - 3574. [Abstract] [Full Text] [PDF]
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J. Wang, L. Weigand, W. Wang, J. T. Sylvester, and L. A. Shimoda Chronic hypoxia inhibits Kv channel gene expression in rat distal pulmonary artery Am J Physiol Lung Cell Mol Physiol, June 1, 2005; 288(6): L1049 - L1058. [Abstract] [Full Text] [PDF]
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T. S. Fisher, S. D. Etages, L. Hayes, K. Crimin, and B. Li Analysis of ARD1 Function in Hypoxia Response Using Retroviral RNA Interference J. Biol. Chem., May 6, 2005; 280(18): 17749 - 17757. [Abstract] [Full Text] [PDF]
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M. Nikinmaa and B. B. Rees Oxygen-dependent gene expression in fishes Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1079 - R1090. [Abstract] [Full Text] [PDF]
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A. Wagatsuma, H. Tamaki, and F. Ogita Capillary supply and gene expression of angiogenesis-related factors in murine skeletal muscle following denervation Exp Physiol, May 1, 2005; 90(3): 403 - 409. [Abstract] [Full Text] [PDF]
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 W.-T. Chen, C.-J. Huang, M.-T. Wu, S.-F. Yang, Y.-C. Su, and C.-Y. Chai Hypoxia-inducible Factor-1{alpha} is Associated with Risk of Aggressive Behavior and Tumor Angiogenesis in Gastrointestinal Stromal Tumor Jpn. J. Clin. Oncol., April 1, 2005; 35(4): 207 - 213. [Abstract] [Full Text] [PDF]
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P. van Wijngaarden, D. J. Coster, H. M. Brereton, I. L. Gibbins, and K. A. Williams Strain-Dependent Differences in Oxygen-Induced Retinopathy in the Inbred Rat Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1445 - 1452. [Abstract] [Full Text] [PDF]
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 E. F. M. Wouters Local and Systemic Inflammation in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, April 1, 2005; 2(1): 26 - 33. [Abstract] [Full Text] [PDF]
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Y. Cao, A. Hong, H. Schulten, and M. J. Post Update on therapeutic neovascularization Cardiovasc Res, February 15, 2005; 65(3): 639 - 648. [Abstract] [Full Text] [PDF]
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M. F. Banks, E. V. Gerasimovskaya, D. A. Tucker, M. G. Frid, T. C. Carpenter, and K. R. Stenmark Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts J Appl Physiol, February 1, 2005; 98(2): 732 - 738. [Abstract] [Full Text] [PDF]
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G. B. Waypa and P. T. Schumacker Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing J Appl Physiol, January 1, 2005; 98(1): 404 - 414. [Abstract] [Full Text] [PDF]
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U. Meissner, C. Hanisch, I. Ostreicher, I. Knerr, K.-H. Hofbauer, W. F. Blum, I. Allabauer, W. Rascher, and J. Dotsch Differential Regulation of Leptin Synthesis in Rats during Short-Term Hypoxia and Short-Term Carbon Monoxide Inhalation Endocrinology, January 1, 2005; 146(1): 215 - 220. [Abstract] [Full Text] [PDF]
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 T. L. Van Natta, J. C. Ralphe, C. E. Mascio, K. A. Bedell, T. D. Scholz, and J. L. Segar Ontogeny of Vascular Growth Factors in Perinatal Sheep Myocardium Reproductive Sciences, December 1, 2004; 11(8): 503 - 510. [Abstract] [PDF]
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 T. Tanaka, T. Miyata, R. Inagi, T. Fujita, and M. Nangaku Hypoxia in Renal Disease with Proteinuria and/or Glomerular Hypertension Am. J. Pathol., December 1, 2004; 165(6): 1979 - 1992. [Abstract] [Full Text] [PDF]
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N. Morita, K. Iizuka, K. Okita, T. Oikawa, K. Yonezawa, T. Nagai, Y. Tokumitsu, T. Murakami, A. Kitabatake, and H. Kawaguchi Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1064 - E1069. [Abstract] [Full Text] [PDF]
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 W. H. Dragowska, C. Warburton, D. T.T. Yapp, A. I. Minchinton, Y. Hu, D. N. Waterhouse, K. Gelmon, K. Skov, J. Woo, D. Masin, et al. HER-2/neu Overexpression Increases the Viable Hypoxic Cell Population within Solid Tumors without Causing Changes in Tumor Vascularization Mol. Cancer Res., November 1, 2004; 2(11): 606 - 619. [Abstract] [Full Text] [PDF]
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K. K. K. Sheares, T. K. Jeffery, L. Long, X. Yang, and N. W. Morrell Differential effects of TGF-{beta}1 and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L919 - L927. [Abstract] [Full Text] [PDF]
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 H. K. Eltzschig and C. D. Collard Vascular ischaemia and reperfusion injury Br. Med. Bull., October 19, 2004; 70(1): 71 - 86. [Abstract] [Full Text] [PDF]
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K. Hirota, R. Fukuda, S. Takabuchi, S. Kizaka-Kondoh, T. Adachi, K. Fukuda, and G. L. Semenza Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling J. Biol. Chem., October 1, 2004; 279(40): 41521 - 41528. [Abstract] [Full Text] [PDF]
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 I. Serganova, M. Doubrovin, J. Vider, V. Ponomarev, S. Soghomonyan, T. Beresten, L. Ageyeva, A. Serganov, S. Cai, J. Balatoni, et al. Molecular Imaging of Temporal Dynamics and Spatial Heterogeneity of Hypoxia-Inducible Factor-1 Signal Transduction Activity in Tumors in Living Mice Cancer Res., September 1, 2004; 64(17): 6101 - 6108. [Abstract] [Full Text] [PDF]
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M. C. Tissot van Patot, J. Bendrick-Peart, V. E. Beckey, N. Serkova, and L. Zwerdlinger Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L525 - L532. [Abstract] [Full Text] [PDF]
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