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J Appl Physiol 88: 1438-1445, 2000;
8750-7587/00 $5.00
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Vol. 88, Issue 4, 1438-1445, April 2000

A new model of chronic cardiac ischemia in rabbits

Christine Operschall1, Loretta Falivene1, Jean-Paul Clozel2, and Sébastien Roux1

1 Pharma Division, Cardiovascular Preclinical Research, F. Hoffmann-La Roche Ltd., 4070 Basel; and 2 Actelion Ltd., 4123 Allschwil, Switzerland

Chronic cardiac ischemia has mainly been studied in large species such as pigs or dogs. Little research has been performed using small species such as rabbits. In the present study, 1-3 wk after implantation of a novel device (ameroid) on the circumflex coronary artery of New Zealand White rabbits, vessel patency was evaluated by coronary angiography, corrosion cast, and radiolabeled microspheres. Coronary angiograms showed, after 21 days, either total occlusion or severe stenosis in seven of eight arteries, which was confirmed by corrosion casts. The ameroid group had less blood flow in the epicardial (-62%) and endocardial (-54%) layers of the ischemic area compared with sham-operated rabbits (P < 0.05). Blood flow increased in the ischemic area compared with day 0 during acute occlusion, suggesting that progressive coronary occlusion initiated the growth of de novo collateral vessels. Thus we have developed a new model of chronic cardiac ischemia in rabbits with documented progressive coronary stenosis and occlusion that is suitable to test various therapeutic angiogenesis strategies.

heart; coronary circulation; angiogenesis; regional blood flow


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