Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1271-1276, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tajima, O.
Right arrow Articles by Suzuki, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tajima, O.
Right arrow Articles by Suzuki, M.
Vol. 88, Issue 4, 1271-1276, April 2000

Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism

Orie Tajima1, Noriko Ashizawa2, Tomoo Ishii3, Hitoshi Amagai4, Tomoko Mashimo1, Li Jing Liu1, Shinichi Saitoh1, Kumpei Tokuyama1, and Masashige Suzuki1

1 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574; 2 National Cancer Center, Tokyo 104-0043; 3 Institute of Clinical Medical Science, University of Tsukuba, Tsukuba, Ibaraki 305-0006; and 4 Tsukuba College of Medical Technology and Nursing, Tsukuba, Ibaraki 305-0006, Japan

Bone metabolism is strongly influenced by heredity and environmental factors. To investigate interaction of the effects between vitamin D receptor polymorphism by Fok I and resistance exercise training on bone metabolism, young male subjects with FF genotype (F, n = 10) and Ff or ff genotypes (f, n = 10) followed 1 mo of weight training, and changes in bone metabolism were compared. An additional 14 subjects served as a sedentary control. Biomarkers of bone formation, bone-specific alkaline phosphatase, and osteocalcin were significantly increased by training in both F and f groups. 1,25-Dihydroxyvitamin D3, known to upregulate bone formation, was also increased by the training in the f but not in the F group. Bone resorption assessed by cross-linked NH2-terminal teropeptide of type I collagen was significantly suppressed by the training, and the decrease in F was greater and longer lasting than that in f group. In conclusion, stimulation of bone formation and suppression of bone resorption occurred within 1 mo in young men. Despite a significant increase in 1,25-dihydroxyvitamin D3 in the f group but not in the F group, the response of bone metabolism to the training in the F was similar to or greater than that in f group, suggesting a functional difference between vitamin D receptor genotypes f and F.

Fok I; bone formation; bone resorption


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Kesavan, S. Mohan, S. Oberholtzer, J. E. Wergedal, and D. J. Baylink
Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains
J Appl Physiol, November 1, 2005; 99(5): 1951 - 1957.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Seeman
Invited Review: Pathogenesis of osteoporosis
J Appl Physiol, November 1, 2003; 95(5): 2142 - 2151.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. Nakamura, T. Ishii, Y. Ando, H. Amagai, M. Oto, T. Imafuji, and K. Tokuyama
Potential role of vitamin D receptor gene polymorphism in determining bone phenotype in young male athletes
J Appl Physiol, December 1, 2002; 93(6): 1973 - 1979.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online