Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1265-1270, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (49)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blough, E. R.
Right arrow Articles by Linderman, J. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blough, E. R.
Right arrow Articles by Linderman, J. K.
Vol. 88, Issue 4, 1265-1270, April 2000

Lack of skeletal muscle hypertrophy in very aged male Fischer 344 × Brown Norway rats

E. R. Blough and J. K. Linderman

Laboratory of Basic and Applied Myology, School of Physical Activity and Educational Services, Ohio State University, Columbus, Ohio 43210-1284

To examine the effect of extreme old age on muscle plasticity, 6- (adult) and 36-mo-old (old) male Fischer 344 × Brown Norway hybrid rats underwent bilateral surgical ablation of the gastrocnemius muscle to functionally overload (OV) the fast-twitch plantaris muscle for 8 wk. Plantaris muscle wet weight, muscle cross-sectional area (CSA), and average fiber CSA decreased by 44, 42, and 40%, respectively, in old compared with adult rats, and peak isometric tetanic tension decreased by 83%. Compared with muscles in age-matched controls, plantaris muscle mass increased by 53% and type I, IIA, and IIX/IIB CSA increased by 91, 76, and 103%, respectively, in adult-OV rats, but neither wet mass nor fiber CSA increased in old-OV rats. OV decreased type I, IIA, and IIX/IIB mean fiber CSA by 31, 35, and 30%, respectively, in old-OV rats. Collectively, our data indicate that in extreme old age the plantaris muscle undergoes significant loss of mass, fiber CSA, and contractile function, as well as its capacity to undergo hypertrophy in response to a chronic increase in mechanical load.

sarcopenia; myosin


This article has been cited by other articles:


Home page
 J Gerontol A Biol Sci Med SciHome page
A. Chale-Rush, E. P. Morris, T. L. Kendall, N. E. Brooks, and R. A. Fielding
Effects of Chronic Overload on Muscle Hypertrophy and mTOR Signaling in Young Adult and Aged Rats
J Gerontol A Biol Sci Med Sci, December 1, 2009; 64A(12): 1232 - 1239.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Betik, M. M. Thomas, K. J. Wright, C. D. Riel, and R. T. Hepple
Exercise training from late middle age until senescence does not attenuate the declines in skeletal muscle aerobic function
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2009; 297(3): R744 - R755.
[Abstract] [Full Text] [PDF]

Home page
 J Gerontol A Biol Sci Med SciHome page
D. T. Hwee and S. C. Bodine
Age-Related Deficit in Load-Induced Skeletal Muscle Growth
J Gerontol A Biol Sci Med Sci, June 1, 2009; 64A(6): 618 - 628.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
J. M. Gonzalez, J. N. Carter, D. D. Johnson, S. E. Ouellette, and S. E. Johnson
Effect of ractopamine-hydrochloride and trenbolone acetate on longissimus muscle fiber area, diameter, and satellite cell numbers in cull beef cows
J Anim Sci, August 1, 2007; 85(8): 1893 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
K. M. Rice, D. L. Preston, D. Neff, M. Norton, and E. R. Blough
Age-Related Dystrophin-Glycoprotein Complex Structure and Function in the Rat Extensor Digitorum Longus and Soleus Muscle
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1119 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. M. Thomson and S. E. Gordon
Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle
J. Physiol., July 1, 2006; 574(1): 291 - 305.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
J Appl Physiol, April 1, 2006; 100(4): 1188 - 1203.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Funai, J. D. Parkington, S. Carambula, and R. A. Fielding
Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R1080 - R1086.
[Abstract] [Full Text] [PDF]

Home page
 Sci Aging Knowl EnvironHome page
R. T. Hepple
Dividing to Keep Muscle Together: The Role of Satellite Cells in Aging Skeletal Muscle
Sci. Aging Knowl. Environ., January 18, 2006; 2006(3): pe3 - pe3.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. M. Siu and S. E. Alway
Age-related apoptotic responses to stretch-induced hypertrophy in quail slow-tonic skeletal muscle
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1105 - C1113.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. M. Siu, E. E. Pistilli, and S. E. Alway
Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1015 - R1026.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. M. Thomson and S. E. Gordon
Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
J Appl Physiol, February 1, 2005; 98(2): 557 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. M. Siu, E. E. Pistilli, D. C. Butler, and S. E. Alway
Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C338 - C349.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. C. Gallegly, N. A. Turesky, B. A. Strotman, C. M. Gurley, C. A. Peterson, and E. E. Dupont-Versteegden
Satellite cell regulation of muscle mass is altered at old age
J Appl Physiol, September 1, 2004; 97(3): 1082 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. D. Parkington, N. K. LeBrasseur, A. P. Siebert, and R. A. Fielding
Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle
J Appl Physiol, July 1, 2004; 97(1): 243 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
R. T. Hepple, K. D. Ross, and A. B. Rempfer
Fiber Atrophy and Hypertrophy in Skeletal Muscles of Late Middle-Aged Fischer 344 x Brown Norway F1-Hybrid Rats
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2004; 59(2): B108 - 117.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. T. Morris, E. E. Spangenburg, and F. W. Booth
Responsiveness of cell signaling pathways during the failed 15-day regrowth of aged skeletal muscle
J Appl Physiol, January 1, 2004; 96(1): 398 - 404.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Pattison, L. C. Folk, R. W. Madsen, and F. W. Booth
Selected Contribution: Identification of differentially expressed genes between young and old rat soleus muscle during recovery from immobilization-induced atrophy
J Appl Physiol, November 1, 2003; 95(5): 2171 - 2179.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. J. Lee, J. McClung, G. A. Hand, and J. A. Carson
Overload-induced androgen receptor expression in the aged rat hindlimb receiving nandrolone decanoate
J Appl Physiol, March 1, 2003; 94(3): 1153 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. E. Spangenburg, T. Abraha, T. E. Childs, J. S. Pattison, and F. W. Booth
Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent
Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E340 - E350.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. W. Booth, M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
J Appl Physiol, July 1, 2002; 93(1): 3 - 30.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Carson, W. J. Lee, J. McClung, and G. A. Hand
Steroid receptor concentration in aged rat hindlimb muscle: effect of anabolic steroid administration
J Appl Physiol, July 1, 2002; 93(1): 242 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. E. Alway, H. Degens, G. Krishnamurthy, and C. A. Smith
Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C66 - C76.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. E. Alway, H. Degens, D. A. Lowe, and G. Krishnamurthy
Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R411 - R422.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
C. T. Putman, K. R. Sultan, T. Wassmer, J. A. Bamford, D. Skorjanc, and D. Pette
Fiber-Type Transitions and Satellite Cell Activation in Low-Frequency-Stimulated Muscles of Young and Aging Rats
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2001; 56(12): B510 - 519.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
S.M. Roth, G.F. Martel, F.M. Ivey, J.T. Lemmer, B.L. Tracy, E.J. Metter, B.F. Hurley, and M.A. Rogers
Skeletal Muscle Satellite Cell Characteristics in Young and Older Men and Women After Heavy Resistance Strength Training
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2001; 56(6): B240 - B247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Barazzoni and K. S. Nair
Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E413 - E419.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online