Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 1259-1264, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milanese, M.
Right arrow Articles by Brusasco, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milanese, M.
Right arrow Articles by Brusasco, V.
Vol. 88, Issue 4, 1259-1264, April 2000

Modulation of airway caliber by deep inhalation in children

Manlio Milanese, Chiara Mondino, Mariangela Tosca, G. Walter Canonica, and Vito Brusasco

Centro di Fisiopatologia Respiratoria, Dipartimento di Scienze Motorie e Riabilitative e Clinica delle Malattie dell' Apparato Respiratorio ed Allergologia, Dipartimento di Medicina Interna, Università di Genova, 16132 Genova, Italy

To elucidate whether deep inhalation (DI) modulates changes in airway caliber in childhood, we measured the effect of DI on respiratory impedance before and after inhaled methacholine or salbutamol in 4- to 7-yr-old children (n = 15) suffering from recurrent wheezing. In all children, the real part of impedance between 12 and 16 Hz (Re[Z]12-16) increased after methacholine from 5.6 ± 1.2 to 8.2 ± 1.6 cmH2O · l-1 · s (P < 0.001) and resonance frequency from 18 ± 3 to 25 ± 5 Hz (P < 0.001). These changes were partially reversed by DI: Re[Z]12-16 decreased to 7.2 ± 1.2 cmH2O · l-1 · s (P < 0.01) and resonance frequency to 19 ± 5 Hz (P < 0.001). In nine children, on a separate occasion, Re[Z]12-16 decreased after salbutamol from 8.3 ± 1.9 to 5.1 ± 0.9 cmH2O · l-1 · s (P < 0.001) and resonance frequency from 21 ± 6 to 15 ± 3 Hz (P < 0.05). The decrease of Re[Z]12-16 was partially reversed by DI (to 6.2 ± 1.4 cmH2O · l-1 · s, P < 0.01), but resonance frequency did not change significantly (P = 0.75). We conclude that in 4- to 7-yr-old children pharmacologically induced changes in airway caliber are modulated by DI. These findings suggest that airway-to-parenchyma interdependence is operative in this age range.

respiratory resistance; resonance frequency; bronchoconstriction; bronchodilatation; forced-oscillation technique; wheezing


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
N. Beydon, S. D. Davis, E. Lombardi, J. L. Allen, H. G. M. Arets, P. Aurora, H. Bisgaard, G. M. Davis, F. M. Ducharme, H. Eigen, et al.
An Official American Thoracic Society/European Respiratory Society Statement: Pulmonary Function Testing in Preschool Children
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1304 - 1345.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Schweitzer, C. Moreau-Colson, and F. Marchal
Respiratory impedance response to a deep inhalation in asthmatic children with spontaneous airway obstruction
Eur. Respir. J., June 1, 2002; 19(6): 1020 - 1025.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online