Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 981-986, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hanson, W. L.
Right arrow Articles by Wagner, W. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hanson, W. L.
Right arrow Articles by Wagner, W. W., Jr.
Vol. 88, Issue 3, 981-986, March 2000

Pulmonary vascular response of the coati to chronic hypoxia

Wendy L. Hanson1,4, Dona F. Boggs4,5, J. Michael Kay6, Stephen E. Hofmeister4, Osamu Okada7, and Wiltz W. Wagner Jr.1,2,3,4

Departments of 1 Anesthesia, 2 Physiology/Biophysics, and 3 Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202; 4 Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver, Colorado 80262; 5 Biology Department, Eastern Washington University, Cheney, Washington 99004; 6 Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 4A6; and 7 Department of Chest Medicine, Chiba University School of Medicine, Chiba 260-8670, Japan

The unusually muscular pulmonary arteries normally present in cattle and swine residing at low altitude are associated with a rapid development of severe pulmonary hypertension when those animals are moved to high altitude. Because these species lack collateral ventilation, they appear to have an increased dependence on hypoxic vasoconstriction to maintain normal ventilation-perfusion balance, which, in turn, maintains thickened arterial walls. The only other species known to lack collateral ventilation is the coati, which, similarly, has thick-walled pulmonary arteries. We tested the hypothesis that coatis will develop severe high-altitude pulmonary hypertension by exposing six of these animals (Nasua narica) to a simulated altitude of 4,900 m for 6 wk. After the exposure, pulmonary arterial pressures were hardly elevated, right ventricular hypertrophy was minimal, there was no muscularization of pulmonary arterioles, and, most surprising of all, there was a decrease in medial thickness of muscular pulmonary arteries. These unexpected results break a consistent cross-species pattern in which animals with thick muscular pulmonary arteries at low altitude develop severe pulmonary hypertension at high altitude.

collateral ventilation; species variation to hypoxia; pulmonary hypertension; high altitude; distal arterial muscularization; medial thickness; vascular smooth muscle; Nasua narica


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. Rhodes
Comparative physiology of hypoxic pulmonary hypertension: historical clues from brisket disease
J Appl Physiol, March 1, 2005; 98(3): 1092 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
Y. Hoshikawa, P. Nana-Sinkam, M. D. Moore, S. Sotto-Santiago, T. Phang, R. L. Keith, K. G. Morris, T. Kondo, R. M. Tuder, N. F. Voelkel, et al.
Hypoxia induces different genes in the lungs of rats compared with mice
Physiol Genomics, February 6, 2003; 12(3): 209 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Y. HOSHIKAWA, N. F. VOELKEL, T. L. GESELL, M. D. MOORE, K. G. MORRIS, L. A. ALGER, S. NARUMIYA, and M. W. GERACI
Prostacyclin Receptor-dependent Modulation of Pulmonary Vascular Remodeling
Am. J. Respir. Crit. Care Med., July 15, 2001; 164(2): 314 - 318.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online