Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 88: 926-932, 2000;
8750-7587/00 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jellinek, H.
Right arrow Articles by Fitzgerald, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jellinek, H.
Right arrow Articles by Fitzgerald, R. D.
Vol. 88, Issue 3, 926-932, March 2000

Influence of positive airway pressure on the pressure gradient for venous return in humans

H. Jellinek1, H. Krenn1, W. Oczenski1, F. Veit2, S. Schwarz1, and R. D. Fitzgerald3

1 Department of Anesthesiology and Intensive Care Medicine, 2 First Department of Surgery, and 3 Ludwig Boltzmann Institute of Economics of Medicine in Anesthesia and Intensive Care, Community Hospital of Lainz, A-1130 Vienna, Austria

To study the effect of positive airway pressure (Paw) on the pressure gradient for venous return [the difference between mean systemic filling pressure (Pms) and right atrial pressure (Pra)], we investigated 10 patients during general anesthesia for implantation of defibrillator devices. Paw was varied under apnea from 0 to 15 cmH2O, which increased Pra from 7.3 ± 3.1 to 10.0 ± 2.3 mmHg and decreased left ventricular stroke volume by 23 ± 22%. Episodes of ventricular fibrillation, induced for defibrillator testing, were performed during 0- and 15-cmH2O Paw to measure Pms (value of Pra 7.5 s after onset of circulatory arrest). Positive Paw increased Pms from 10.2 ± 3.5 to 12.7 ± 3.2 mmHg, and thus the pressure gradient for venous return (Pms - Pra) remained unchanged. Echocardiography did not reveal signs of vascular collapse of the inferior and superior vena cava due to lung expansion. In conclusion, we demonstrated that positive Paw equally increases Pra and Pms in humans and alters venous return without changes in the pressure gradient (Pms - Pra).

mean systemic filling pressure; positive end-expiratory pressure; right atrial pressure; mechanical ventilation


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Mitchell, W. A. Whitelaw, R. Sas, E. R. Smith, J. V. Tyberg, and I. Belenkie
RV filling modulates LV function by direct ventricular interaction during mechanical ventilation
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H549 - H557.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. D. Schipke, G. Heusch, A. P. Sanii, E. Gams, and J. Winter
Static filling pressure in patients during induced ventricular fibrillation
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2510 - H2515.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. Malhotra, V. V. Muse, and E. J. Mark
Case 12-2003 - An 82-Year-Old Man with Dyspnea and Pulmonary Abnormalities
N. Engl. J. Med., April 17, 2003; 348(16): 1574 - 1585.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online